Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 (EC 3.1.3.27) (PTEN-like phosphatase) (Phosphoinositide lipid phosphatase) (Protein-tyrosine phosphatase mitochondrial 1) (EC 3.1.3.16) (EC 3.1.3.48)
1_MAATA 6_ LLEAG 11_ LARVL 16_ FYPTL 21_ LYTLF 26_ RGKVP 31_ GRAHR 36_ DWYHR 41_ IDPTV 46_ LLGAL 51_ PLRSL 56_ TRQLV 61_ QDENV 66_ RGVIT 71_ MNEEY 76_ ETRFL 81_ CNSSQ 86_ EWKRL 91_ GVEQL 96_ RLSTV 101_ DMTGI 106_ PTLDN 111_ LQKGV 116_ QFALK 121_ YQSLG 126_ QCVYV 131_ HCKAG 136_ RSRSA 141_ TMVAA 146_ YLIQV 151_ HKWSP 156_ EEAVR 161_ AIAKI 166_ RSYIH 171_ IRPGQ 176_ LDVLK 181_ EFHKQ 186_ ITARA 191_ TKDGT 196_FVISK
1: Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) (By similarity). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle (By similarity). Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production (By similarity). Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues (By similarity). Probably involved in regulation of insulin secretion in pancreatic beta cells (By similarity). May prevent intrinsic apoptosis, probably by regulating mitochondrial membrane integrity (PubMed:24709986)