Filamin-binding LIM protein 1 (FBLP-1) (Migfilin) (Mitogen-inducible 2-interacting protein) (MIG2-interacting protein)
1_MASKP 6_ EKRVA 11_ SSVFI 16_ TLAPP 21_ RRDVA 26_ VAEEV 31_ RQAVC 36_ EARRG 41_ RPWEA 46_ PAPMK 51_ TPEAG 56_ LAGRP 61_ SPWTT 66_ PGRAA 71_ ATVPA 76_ APMQL 81_ FNGGC 86_ PPPPP 91_ VLDGE 96_ DVLPD 101_ LDLLP 106_ PPPPP 111_ PPVLL 116_ PSEEE 121_ APAPM 126_ GASLI 131_ ADLEQ 136_ LHLSP 141_ PPPPP 146_ QAPAE 151_ GPSVQ 156_ PGPLR 161_ PMEEE 166_ LPPPP 171_ AEPVE 176_ KGAST 181_ DICAF 186_ CHKTV 191_ SPREL 196_ AVEAM 201_ KRQYH 206_ AQCFT 211_ CRTCR 216_ RQLAG 221_ QSFYQ 226_ KDGRP 231_ LCEPC 236_ YQDTL 241_ ERCGK 246_ CGEVV 251_ RDHII 256_ RALGQ 261_ AFHPS 266_ CFTCV 271_ TCARC 276_ IGDES 281_ FALGS 286_ QNEVY 291_ CLDDF 296_ YRKFA 301_ PVCSI 306_ CENPI 311_ IPRDG 316_ KDAFK 321_ IECMG 326_ RNFHE 331_ NCYRC 336_ EDCRI 341_ LLSVE 346_ PTDQG 351_ CYPLN 356_ NHLFC 361_ KPCHV 366_KRSAA
1: Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin-containing signaling complexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion