Sodium-coupled neutral amino acid transporter 5 (Solute carrier family 38 member 5) (System N transporter 2)
1_MELQD 6_ PKMNG 11_ ALPSD 16_ AVGYR 21_ QEREG 26_ FLPSR 31_ GPAPG 36_ SKPVQ 41_ FMDFE 46_ GKTSF 51_ GMSVF 56_ NLSNA 61_ IMGSG 66_ ILGLA 71_ YAMAH 76_ TGVIF 81_ FLALL 86_ LCIAL 91_ LSSYS 96_ IHLLL 101_ TCAGI 106_ AGIRA 111_ YEQLG 116_ QRAFG 121_ PAGKV 126_ VVATV 131_ ICLHN 136_ VGAMS 141_ SYLFI 146_ IKSEL 151_ PLVIG 156_ TFLYM 161_ DPEGD 166_ WFLKG 171_ NLLII 176_ IVSVL 181_ IILPL 186_ ALMKH 191_ LGYLG 196_ YTSGL 201_ SLTCM 206_ LFFLV 211_ SVIYK 216_ KFQLG 221_ CAIGH 226_ NETAM 231_ ESEAL 236_ VGLPS 241_ QGLNS 246_ SCEAQ 251_ MFTVD 256_ SQMSY 261_ TVPIM 266_ AFAFV 271_ CHPEV 276_ LPIYT 281_ ELCRP 286_ SKRRM 291_ QAVAN 296_ VSIGA 301_ MFCMY 306_ GLTAT 311_ FGYLT 316_ FYSSV 321_ KAEML 326_ HMYSQ 331_ KDPLI 336_ LCVRL 341_ AVLLA 346_ VTLTV 351_ PVVLF 356_ PIRRA 361_ LQQLL 366_ FPGKA 371_ FSWPR 376_ HVAIA 381_ LILLV 386_ LVNVL 391_ VICVP 396_ TIRDI 401_ FGVIG 406_ STSAP 411_ SLIFI 416_ LPSIF 421_ YLRIV 426_ PSEVE 431_ PFLSW 436_ PKIQA 441_ LCFGV 446_ LGVLF 451_ MAVSL 456_ GFMFA 461_ NWATG 466_QSRMS
1: Symporter that cotransports neutral amino acids and sodium ions, coupled to an H(+) antiporter activity (PubMed:11243884). Releases L-glutamine and glycine from astroglial cells and may participate in the glutamate/GABA-L-glutamine cycle and the NMDA receptors activation (By similarity). In addition, contributes significantly to L-glutamine uptake in retina, namely in ganglion and Mueller cells therefore, participates in the retinal glutamate-glutamine cycle (By similarity). The transport activity is pH sensitive and Li(+) tolerant (PubMed:11243884). Moreover functions in both direction and is associated with large uncoupled fluxes of protons (By similarity). The transport is electroneutral coupled to the cotransport of 1 Na(+) and the antiport of 1 H(+) (By similarity). May have a particular importance for modulation of net hepatic glutamine flux (By similarity)