Non-structural maintenance of chromosomes element 1 homolog (Non-SMC element 1 homolog) (EC 2.3.2.27)
1_MQGST 6_ RRMGV 11_ MTDVH 16_ RRFLQ 21_ LLMTH 26_ GVLEE 31_ WDVKR 36_ LQTHC 41_ YKVHD 46_ RNATV 51_ DKLED 56_ FINNI 61_ NSVLE 66_ SLYIE 71_ IKRGV 76_ TEDDG 81_ RPIYA 86_ LVNLA 91_ TTSIS 96_ KMATD 101_ FAENE 106_ LDLFR 111_ KALEL 116_ IIDSE 121_ TGFAS 126_ STNIL 131_ NLVDQ 136_ LKGKK 141_ MRKKE 146_ AEQVL 151_ QKFVQ 156_ NKWLI 161_ EKEGE 166_ FTLHG 171_ RAILE 176_ MEQYI 181_ RETYP 186_ DAVKI 191_ CNICH 196_ SLLIQ 201_ GQSCE 206_ TCGIR 211_ MHLPC 216_ VAKYF 221_ QSNAE 226_ PRCPH 231_ CNDYW 236_ PHEIP 241_ KVFDP 246_ EKERE 251_ SGVLK 256_ SNKKS 261_LRSRQ
1: RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Within MAGE-RING ubiquitin ligase complex, MAGE stimulates and specifies ubiquitin ligase activity likely through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex. Involved in maintenance of genome integrity, DNA damage response and DNA repair (PubMed:20864041, PubMed:29225034). NSMCE3/MAGEG1 and NSMCE1 ubiquitin ligase are components of SMC5-SMC6 complex and may positively regulate homologous recombination-mediated DNA repair (PubMed:18086888). MAGEF1-NSMCE1 ubiquitin ligase promotes proteasomal degradation of MMS19, a key component of the cytosolic iron-sulfur protein assembly (CIA) machinery. Down-regulation of MMS19 impairs the activity of several DNA repair and metabolism enzymes such as ERCC2/XPD, FANCJ, RTEL1 and POLD1 that require iron-sulfur clusters as cofactors (PubMed:29225034)