B-cell linker protein (B-cell adapter containing a SH2 domain protein) (B-cell adapter containing a Src homology 2 domain protein) (Cytoplasmic adapter protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65)
1_MDKLN 6_ KITVP 11_ ASQKL 16_ RQLQK 21_ MVHDI 26_ KNNEG 31_ GIMNK 36_ IKKLK 41_ VKAPP 46_ SVPRR 51_ DYASE 56_ SPADE 61_ EEQWS 66_ DDFDS 71_ DYENP 76_ DEHSD 81_ SEMYV 86_ MPAEE 91_ NADDS 96_ YEPPP 101_ VEQET 106_ RPVHP 111_ ALPFA 116_ RGEYI 121_ DNRSS 126_ QRHSP 131_ PFSKT 136_ LPSKP 141_ SWPSE 146_ KARLT 151_ STLPA 156_ LTALQ 161_ KPQVP 166_ PKPKG 171_ LLEDE 176_ ADYVV 181_ PVEDN 186_ DENYI 191_ HPTES 196_ SSPPP 201_ EKAPM 206_ VNRST 211_ KPNSS 216_ TPASP 221_ PGTAS 226_ GRNSG 231_ AWETK 236_ SPPPA 241_ APSPL 246_ PRAGK 251_ KPTTP 256_ LKTTP 261_ VASQQ 266_ NASSV 271_ CEEKP 276_ IPAER 281_ HRGSS 286_ HRQEA 291_ VQSPV 296_ FPPAQ 301_ KQIHQ 306_ KPIPL 311_ PRFTE 316_ GGNPT 321_ VDGPL 326_ PSFSS 331_ NSTIS 336_ EQEAG 341_ VLCKP 346_ WYAGA 351_ CDRKS 356_ AEEAL 361_ HRSNK 366_ DGSFL 371_ IRKSS 376_ GHDSK 381_ QPYTL 386_ VVFFN 391_ KRVYN 396_ IPVRF 401_ IEATK 406_ QYALG 411_ RKKNG 416_ EEYFG 421_ SVAEI 426_ IRNHQ 431_ HSPLV 436_ LIDSQ 441_ NNTKD 446_ STRLK 451_YAVKV
1: Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis