Sorting nexin-33 (SH3 and PX domain-containing protein 3)
1_MALKG 6_ RALYD 11_ FHSEN 16_ KEEIS 21_ IQQDE 26_ DLVIF 31_ SETSL 36_ DGWLQ 41_ GQNSR 46_ GETGL 51_ FPASY 56_ VEIVR 61_ SGIST 66_ NHADY 71_ SSSPA 76_ GSPGA 81_ QVSLY 86_ NSPSV 91_ ASPAR 96_ SGGGS 101_ GFLSN 106_ QGSFE 111_ EDDDD 116_ DWDDW 121_ DDGCT 126_ VVEEP 131_ RAGGL 136_ GTNGH 141_ PPLNL 146_ SYPGA 151_ YPSQH 156_ MAFRP 161_ KPPLE 166_ RQDSL 171_ ASAKR 176_ GSVVG 181_ RNLNR 186_ FSCFV 191_ RSGVE 196_ AFILG 201_ DVPMM 206_ AKIAE 211_ TYSIE 216_ MGPRG 221_ PQWKA 226_ NPHPF 231_ ACSVE 236_ DPTKQ 241_ TKFKG 246_ IKSYI 251_ SYKLT 256_ PTHAA 261_ SPVYR 266_ RYKHF 271_ DWLYN 276_ RLLHK 281_ FTVIS 286_ VPHLP 291_ EKQAT 296_ GRFEE 301_ DFIEK 306_ RKRRL 311_ ILWMD 316_ HMTSH 321_ PVLSQ 326_ YEGFQ 331_ HFLSC 336_ LDDKQ 341_ WKMGK 346_ RRAEK 351_ DEMVG 356_ ASFLL 361_ TFQIP 366_ TEHQD 371_ LQDVE 376_ DRVDT 381_ FKAFS 386_ KKMDD 391_ SVLQL 396_ STVAS 401_ ELVRK 406_ HVGGF 411_ RKEFQ 416_ KLGSA 421_ FQAIS 426_ HSFQM 431_ DPPFC 436_ SEALN 441_ SAISH 446_ TGRTY 451_ EAIGE 456_ MFAEQ 461_ PKNDL 466_ FQMLD 471_ TLSLY 476_ QGLLS 481_ NFPDI 486_ IHLQK 491_ GAFAK 496_ VKESQ 501_ RMSDE 506_ GRMVQ 511_ DEADG 516_ IRRRC 521_ RVVGF 526_ ALQAE 531_ MNHFH 536_ QRREL 541_ DFKHM 546_ MQNYL 551_ RQQIL 556_ FYQRV 561_ GQQLE 566_KTLRM
1: Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the formation of macropinosomes