E3 ubiquitin-protein ligase TRIM41 (EC 2.3.2.27) (RING finger-interacting protein with C kinase) (RINCK) (Tripartite motif-containing protein 41)
1_MAAVA 6_ MTPNP 11_ VQTLQ 16_ EEAVC 21_ AICLD 26_ YFTDP 31_ VSIGC 36_ GHNFC 41_ RVCVT 46_ QLWGG 51_ EDEED 56_ RDELD 61_ REEEE 66_ EDGEE 71_ EEVEA 76_ VGAGA 81_ GWDTP 86_ MRDED 91_ YEGDM 96_ EEEVE 101_ EEEEG 106_ VFWTS 111_ GMSRS 116_ SWDNM 121_ DYVWE 126_ EEDEE 131_ EDLDY 136_ YLGDM 141_ EEEDL 146_ RGEDE 151_ EDEEE 156_ VLEEV 161_ EEEDL 166_ DPVTP 171_ LPPPP 176_ APRRC 181_ FTCPQ 186_ CRKSF 191_ PRRSF 196_ RPNLQ 201_ LANMV 206_ QVIRQ 211_ MHPTP 216_ GRGSR 221_ VTDQG 226_ ICPKH 231_ QEALK 236_ LFCEV 241_ DEEAI 246_ CVVCR 251_ ESRSH 256_ KQHSV 261_ VPLEE 266_ VVQEY 271_ KAKLQ 276_ GHVEP 281_ LRKHL 286_ EAVQK 291_ MKAKE 296_ ERRVT 301_ ELKSQ 306_ MKSEL 311_ AAVAS 316_ EFGRL 321_ TRFLA 326_ EEQAG 331_ LERRL 336_ REMHE 341_ AQLGR 346_ AGAAA 351_ SRLAE 356_ QAAQL 361_ SRLLA 366_ EAQER 371_ SQQGG 376_ LRLLQ 381_ DIKET 386_ FNRCE 391_ EVQLQ 396_ PPEVW 401_ SPDPC 406_ QPHSH 411_ DFLTD 416_ AIVRK 421_ MSRMF 426_ CQAAR 431_ VDLTL 436_ DPDTA 441_ HPALM 446_ LSPDR 451_ RGVRL 456_ AERRQ 461_ EVADH 466_ PKRFS 471_ ADCCV 476_ LGAQG 481_ FRSGR 486_ HYWEV 491_ EVGGR 496_ RGWAV 501_ GAARE 506_ STHHK 511_ EKVGP 516_ GGSSV 521_ GSGDA 526_ SSSRH 531_ HHRRR 536_ RLHLP 541_ QQPLL 546_ QREVW 551_ CVGTN 556_ GKRYQ 561_ AQSST 566_ EQTLL 571_ SPSEK 576_ PRRFG 581_ VYLDY 586_ EAGRL 591_ GFYNA 596_ ETLAH 601_ VHTFS 606_ AAFLG 611_ ERVFP 616_ FFRVL 621_SKGTR
1: E3 ligase that plays essential roles in innate antiviral response (PubMed:28169297, PubMed:29760876, PubMed:29899090, PubMed:31979016). Directly binds to influenza A virus or vesicular stomatitis virus nucleoproteins and targets them for ubiquitination and proteasomal degradation, thereby limiting viral infections (PubMed:28169297, PubMed:29899090, PubMed:31979016). Activates the innate antiviral response by catalyzing monoubiquitination of CGAS, thereby activating CGAS (PubMed:29760876). Also involved in innate antiviral response by mediating 'Lys-63'-linked polyubiquitylation of BCL10 which in turn hubs NEMO for activation of NF-kappa-B and IRF3 pathways (By similarity). Catalyzes the ubiquitin-mediated degradation of other substrates including protein kinase C, ZSCAN21 or TOP3B suggesting additional roles besides its function in immune response (PubMed:17893151, PubMed:33378676)