Mitochondrial coenzyme A diphosphatase NUDT8 (EC 3.6.1.-) (Nucleoside diphosphate-linked moiety X motif 8) (Nudix motif 8)
1_MLPDC 6_ LSAEG 11_ ELRCR 16_ RLLAG 21_ ATARL 26_ RARPA 31_ SAAVL 36_ VPLCS 41_ VRGVP 46_ ALLYT 51_ LRSSR 56_ LTGRH 61_ KGDVS 66_ FPGGK 71_ CDPAD 76_ QDVVH 81_ TALRE 86_ TREEL 91_ GLAVP 96_ EEHVW 101_ GLLRP 106_ VYDPQ 111_ KATVV 116_ PVLAG 121_ VGPLD 126_ PQSLR 131_ PNSEE 136_ VDEVF 141_ ALPLA 146_ HLLQT 151_ QNQGY 156_ THFCR 161_ GGHFR 166_ YTLPV 171_ FLHGP 176_ HRVWG 181_ LTAVI 186_ TEFAL 191_ QLLAP 196_ GTYQP 201_ RLAGL 206_ TCSGA 211_ EGLAR 216_ PKQPL 221_ ASPCQ 226_ ASSTP 231_GLNKG
1: Acyl-CoA diphosphatase that mediates the hydrolysis of a wide range of CoA and CoA esters yielding 3',5'-ADP and the corresponding 4'-phosphopantetheine derivative as products (By similarity). Hydrolyzes short- and medium-chain acyl-CoAs, exhibiting the highest activity toward free CoA, hexanoyl-CoA, and octanoyl-CoA and the lowest activity against acetyl-CoA (By similarity). Exhibits decapping activity towards dpCoA-capped RNAs in vitro (By similarity)