AN1-type zinc finger protein 2B (Arsenite-inducible RNA-associated protein-like protein) (AIRAP-like protein)
1_MEFPD 6_ LGAHC 11_ SEPSC 16_ QRLDF 21_ LPLKC 26_ DACSG 31_ IFCAD 36_ HVAYA 41_ QHHCG 46_ SAYQK 51_ DIQVP 56_ VCPLC 61_ NVPVP 66_ VARGE 71_ PPDRA 76_ VGEHI 81_ DRDCR 86_ SDPAQ 91_ QKRKI 96_ FTNKC 101_ ERAGC 106_ RQREM 111_ MKLTC 116_ ERCSR 121_ NFCIK 126_ HRHPL 131_ DHDCS 136_ GEGHP 141_ TSRAG 146_ LAAIS 151_ RAQAV 156_ ASTST 161_ VPSPS 166_ QTMPS 171_ CTSPS 176_ RATTR 181_ SPSWT 186_ APPVI 191_ ALQNG 196_ LSEDE 201_ ALQRA 206_ LEMSL 211_ AETKP 216_ QVPSC 221_ QEEED 226_ LALAQ 231_ ALSAS 236_ EAEYQ 241_ RQQAQ 246_ SRSSK 251_PSNCS
1: Plays a role in protein homeostasis by regulating both the translocation and the ubiquitin-mediated proteasomal degradation of nascent proteins at the endoplasmic reticulum. It is involved in the regulation of signal-mediated translocation of proteins into the endoplasmic reticulum. It also plays a role in the ubiquitin-mediated proteasomal degradation of proteins for which signal-mediated translocation to the endoplasmic reticulum has failed. May therefore function in the endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (By similarity). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333)