RNA polymerase-associated protein LEO1 (Replicative senescence down-regulated leo1-like protein)
1_MADME 6_ DLFGS 11_ DADSE 16_ AERKD 21_ SDSGS 26_ DSDSD 31_ QENAA 36_ SGSNA 41_ SGSES 46_ DQDER 51_ GDSGQ 56_ PSNKE 61_ LFGDD 66_ SEDEG 71_ ASHHS 76_ GSDNH 81_ SERSD 86_ NRSEA 91_ SERSD 96_ HEDND 101_ PSDVD 106_ QHSGS 111_ EAPND 116_ DEDEG 121_ HRSDG 126_ GSHHS 131_ EAEGS 136_ EKAHS 141_ DDEKW 146_ GREDK 151_ SDQSD 156_ DEKIQ 161_ NSDDE 166_ ERAQG 171_ SDEDK 176_ LQNSD 181_ DDEKM 186_ QNTDD 191_ EERPQ 196_ LSDDE 201_ RQQLS 206_ EEEKA 211_ NSDDE 216_ RPVAS 221_ DNDDE 226_ KQNSD 231_ DEEQP 236_ QLSDE 241_ EKMQN 246_ SDDER 251_ PQASD 256_ EEHRH 261_ SDDEE 266_ EQDHK 271_ SESAR 276_ GSDSE 281_ DEVLR 286_ MKRKN 291_ AIASD 296_ SEADS 301_ DTEVP 306_ KDNSG 311_ TMDLF 316_ GGADD 321_ ISSGS 326_ DGEDK 331_ PPTPG 336_ QPVDE 341_ NGLPQ 346_ DQQEE 351_ EPIPE 356_ TRIEV 361_ EIPKV 366_ NTDLG 371_ NDLYF 376_ VKLPN 381_ FLSVE 386_ PRPFD 391_ PQYYE 396_ DEFED 401_ EEMLD 406_ EEGRT 411_ RLKLK 416_ VENTI 421_ RWRIR 426_ RDEEG 431_ NEIKE 436_ SNARI 441_ VKWSD 446_ GSMSL 451_ HLGNE 456_ VFDVY 461_ KAPLQ 466_ GDHNH 471_ LFIRQ 476_ GTGLQ 481_ GQAVF 486_ KTKLT 491_ FRPHS 496_ TDSAT 501_ HRKMT 506_ LSLAD 511_ RCSKT 516_ QKIRI 521_ LPMAG 526_ RDPEC 531_ QRTEM 536_ IKKEE 541_ ERLRA 546_ SIRRE 551_ SQQRR 556_ MREKQ 561_ HQRGL 566_ SASYL 571_ EPDRY 576_ DEEEE 581_ GEESI 586_ SLAAI 591_ KNRYK 596_ GGIRE 601_ ERARI 606_ YSSDS 611_ DEGSE 616_ EDKAQ 621_ RLLKA 626_ KKLTS 631_ DEEGE 636_ PSGKR 641_ KAEDD 646_ DKANK 651_ KHKKY 656_ VISDE 661_EEEDD
1: Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Involved in polyadenylation of mRNA precursors. Connects PAF1C to Wnt signaling