E3 ubiquitin-protein ligase RNF138 (EC 2.3.2.27) (Nemo-like kinase-associated RING finger protein) (NLK-associated RING finger protein) (hNARF) (RING finger protein 138) (RING-type E3 ubiquitin transferase RNF138)
1_MAEDL 6_ SAATS 11_ YTEDD 16_ FYCPV 21_ CQEVL 26_ KTPVR 31_ TTACQ 36_ HVFCR 41_ KCFLT 46_ AMRES 51_ GAHCP 56_ LCRGN 61_ VTRRE 66_ RACPE 71_ RALDL 76_ ENIMR 81_ KFSGS 86_ CRCCA 91_ KQIKF 96_ YRMRH 101_ HYKSC 106_ KKYQD 111_ EYGVS 116_ SIIPN 121_ FQISQ 126_ DSVGN 131_ SNRSE 136_ TSTSD 141_ NTETY 146_ QENTS 151_ SSGHP 156_ TFKCP 161_ LCQES 166_ NFTRQ 171_ RLLDH 176_ CNSNH 181_ LFQIV 186_ PVTCP 191_ ICVSL 196_ PWGDP 201_ SQITR 206_ NFVSH 211_ LNQRH 216_ QFDYG 221_ EFVNL 226_ QLDEE 231_ TQYQT 236_AVEES
1: E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination (PubMed:26502055, PubMed:26502057). Recruited to sites of double-strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination (PubMed:26502055, PubMed:26502057). Two different, non-exclusive, mechanisms have been proposed. According to a report, regulates the choice of double-strand break repair by favoring homologous recombination over non-homologous end joining (NHEJ): acts by mediating ubiquitination of XRCC5/Ku80, leading to remove the Ku complex from DNA breaks, thereby promoting homologous recombination (PubMed:26502055). According to another report, cooperates with UBE2Ds E2 ubiquitin ligases (UBE2D1, UBE2D2, UBE2D3 or UBE2D4) to promote homologous recombination by mediating ubiquitination of RBBP8/CtIP (PubMed:26502057). Together with NLK, involved in the ubiquitination and degradation of TCF/LEF (PubMed:16714285). Also exhibits auto-ubiquitination activity in combination with UBE2K (PubMed:16714285). May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway (PubMed:16714285)