Twist-related protein 2 (Class A basic helix-loop-helix protein 39) (bHLHa39) (Dermis-expressed protein 1) (Dermo-1)
1_MEEGS 6_ SSPVS 11_ PVDSL 16_ GTSEE 21_ ELERQ 26_ PKRFG 31_ RKRRY 36_ SKKSS 41_ EDGSP 46_ TPGKR 51_ GKKGS 56_ PSAQS 61_ FEELQ 66_ SQRIL 71_ ANVRE 76_ RQRTQ 81_ SLNEA 86_ FAALR 91_ KIIPT 96_ LPSDK 101_ LSKIQ 106_ TLKLA 111_ ARYID 116_ FLYQV 121_ LQSDE 126_ MDNKM 131_ TSCSY 136_ VAHER 141_ LSYAF 146_ SVWRM 151_EGAWS
1: Binds to the E-box consensus sequence 5'-CANNTG-3' as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C. Also represses expression of pro-inflammatory cytokines such as TNFA and IL1B. Involved in postnatal glycogen storage and energy metabolism (By similarity). Inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis, possibly by changing the internal signal transduction response of osteoblasts to external growth factors