Soluble calcium-activated nucleotidase 1 (SCAN-1) (EC 3.6.1.6) (Apyrase homolog) (Putative MAPK-activating protein PM09) (Putative NF-kappa-B-activating protein 107)
1_MPVQL 6_ SEHPE 11_ WNESM 16_ HSLRI 21_ SVGGL 26_ PVLAS 31_ MTKAA 36_ DPRFR 41_ PRWKV 46_ ILTFF 51_ VGAAI 56_ LWLLC 61_ SHRPA 66_ PGRPP 71_ THNAH 76_ NWRLG 81_ QAPAN 86_ WYNDT 91_ YPLSP 96_ PQRTP 101_ AGIRY 106_ RIAVI 111_ ADLDT 116_ ESRAQ 121_ EENTW 126_ FSYLK 131_ KGYLT 136_ LSDSG 141_ DKVAV 146_ EWDKD 151_ HGVLE 156_ SHLAE 161_ KGRGM 166_ ELSDL 171_ IVFNG 176_ KLYSV 181_ DDRTG 186_ VVYQI 191_ EGSKA 196_ VPWVI 201_ LSDGD 206_ GTVEK 211_ GFKAE 216_ WLAVK 221_ DERLY 226_ VGGLG 231_ KEWTT 236_ TTGDV 241_ VNENP 246_ EWVKV 251_ VGYKG 256_ SVDHE 261_ NWVSN 266_ YNALR 271_ AAAGI 276_ QPPGY 281_ LIHES 286_ ACWSD 291_ TLQRW 296_ FFLPR 301_ RASQE 306_ RYSEK 311_ DDERK 316_ GANLL 321_ LSASP 326_ DFGDI 331_ AVSHV 336_ GAVVP 341_ THGFS 346_ SFKFI 351_ PNTDD 356_ QIIVA 361_ LKSEE 366_ DSGRV 371_ ASYIM 376_ AFTLD 381_ GRFLL 386_ PETKI 391_ GSVKY 396_EGIEF
1: Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP (PubMed:12234496, PubMed:15006348, PubMed:15248776, PubMed:16835225). Involved in proteoglycan synthesis (PubMed:22539336)