Cytoplasmic dynein 2 intermediate chain 1 (Dynein 2 intermediate chain 1) (WD repeat-containing protein 60)
1_MEPGK 6_ RRTKD 11_ DTWKA 16_ DDLRK 21_ HLWAI 26_ QSGGS 31_ KEERK 36_ HREKK 41_ LRKES 46_ EMDLP 51_ EHKEP 56_ RCRDP 61_ DQDAR 66_ SRDRV 71_ AEVHT 76_ AKESP 81_ RGERD 86_ RDRQR 91_ ERRRD 96_ AKDRE 101_ KEKLK 106_ EKHRE 111_ AEKSH 116_ SRGKD 121_ REKEK 126_ DRRAR 131_ KEELR 136_ QTVAH 141_ HNLLG 146_ QETRD 151_ RQLLE 156_ RAERK 161_ GRSVS 166_ KVRSE 171_ EKDED 176_ SERGD 181_ EDRER 186_ RYRER 191_ KLQYG 196_ DSKDN 201_ PLKYW 206_ LYKEE 211_ GERRH 216_ RKPRE 221_ PDRDN 226_ KHREK 231_ SSTRE 236_ KREKY 241_ SKEKS 246_ NSFSD 251_ KGEER 256_ HKEKR 261_ HKEGF 266_ HFDDE 271_ RHQSN 276_ VDRKE 281_ KSAKD 286_ EPRKR 291_ ESQNG 296_ EHRNR 301_ GASSK 306_ RDGTS 311_ SQHAE 316_ NLVRN 321_ HGKDK 326_ DSRRK 331_ HGHEE 336_ GSSVW 341_ WKLDQ 346_ RPGGE 351_ ETVEI 356_ EKEET 361_ DLENA 366_ RADAY 371_ TASCE 376_ DDFED 381_ YEDDF 386_ EVCDG 391_ DDDES 396_ SNEPE 401_ SREKL 406_ EELPL 411_ AQKKE 416_ IQEIQ 421_ RAINA 426_ ENERI 431_ GELSL 436_ KLFQK 441_ RGRTE 446_ FEKEP 451_ RTDTN 456_ SSPSR 461_ ASVCG 466_ IFVDF 471_ ASASH 476_ RQKSR 481_ TQALK 486_ QKMRS 491_ TKLLR 496_ LIDLD 501_ FSFTF 506_ SLLDL 511_ PPVNE 516_ YDMYI 521_ RNFGK 526_ KNTKQ 531_ AYVQC 536_ NEDNV 541_ ERDIQ 546_ TEEIE 551_ TREVW 556_ TQHPG 561_ ESTVV 566_ SGGSE 571_ QRDTS 576_ DAVVM 581_ PKIDT 586_ PRLCS 591_ FLRAA 596_ CQVMA 601_ VLLEE 606_ DRLAA 611_ EPSWN 616_ LRAQD 621_ RALYF 626_ SDSSS 631_ QLNTS 636_ LPFLQ 641_ NRKVS 646_ SLHTS 651_ RVQRQ 656_ MVVSV 661_ HDLPE 666_ KSFVP 671_ LLDSK 676_ YVLCV 681_ WDIWQ 686_ PSGPQ 691_ KVLIC 696_ ESQVT 701_ CCCLS 706_ PLKAF 711_ LLFAG 716_ TAHGS 721_ VVVWD 726_ LREDS 731_ RLHYS 736_ VTLSD 741_ GFWTF 746_ RTATF 751_ STDGI 756_ LTSVN 761_ HRSPL 766_ QAVEP 771_ ISTSV 776_ HKKQS 781_ FVLSP 786_ FSTQE 791_ EMSGL 796_ SFHIA 801_ SLDES 806_ GVLNV 811_ WVVVE 816_ LPKAD 821_ IAGSI 826_ SDLGL 831_ MPGGR 836_ VKLVH 841_ SALIQ 846_ LGDSL 851_ SHKGN 856_ EFWGT 861_ TQTLN 866_ VKFLP 871_ SDPNH 876_ FIIGT 881_ DMGLI 886_ SHGTR 891_ QDLRV 896_ APKLF 901_ KPQQH 906_ GIRPV 911_ KVNVI 916_ DFSPF 921_ GEPIF 926_ LAGCS 931_ DGSIR 936_ LHQLS 941_ SAFPL 946_ LQWDS 951_ STDSH 956_ AVTGL 961_ QWSPT 966_ RPAVF 971_ LVQDD 976_ TSNIY 981_ IWDLL 986_ QSDLG 991_ PVAKQ 996_ QVSPN 1001_ RLVAM 1006_ AAVGE 1011_ PEKAG 1016_ GSFLA 1021_ LVLAR 1026_ ASGSI 1031_ DIQHL 1036_ KRRWA 1041_ APEVD 1046_ ECNRL 1051_ RLLLQ 1056_ EALWP 1061_EGKLH
1: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system (PubMed:23910462, PubMed:25205765, PubMed:29742051, PubMed:31451806). DYNC2I1 plays a major role in retrograde ciliary protein trafficking in cilia and flagella (PubMed:29742051, PubMed:30320547, PubMed:30649997). Also requires to maintain a functional transition zone (PubMed:30320547)