Ubiquitin-like domain-containing CTD phosphatase 1 (EC 3.1.3.16) (Nuclear proteasome inhibitor UBLCP1)
1_MALPI 6_ IVKWG 11_ GQEYS 16_ VTTLS 21_ EDDTV 26_ LDLKQ 31_ FLKTL 36_ TGVLP 41_ ERQKL 46_ LGLKV 51_ KGKPA 56_ ENDVK 61_ LGALK 66_ LKPNT 71_ KIMMM 76_ GTREE 81_ SLEDV 86_ LGPPP 91_ DNDDV 96_ VNDFD 101_ IEDEV 106_ VEVEN 111_ REENL 116_ LKISR 121_ RVKEY 126_ KVEIL 131_ NPPRE 136_ GKKLL 141_ VLDVD 146_ YTLFD 151_ HRSCA 156_ ETGVE 161_ LMRPY 166_ LHEFL 171_ TSAYE 176_ DYDIV 181_ IWSAT 186_ NMKWI 191_ EAKMK 196_ ELGVS 201_ TNANY 206_ KITFM 211_ LDSAA 216_ MITVH 221_ TPRRG 226_ LIDVK 231_ PLGVI 236_ WGKFS 241_ EFYSK 246_ KNTIM 251_ FDDIG 256_ RNFLM 261_ NPQNG 266_ LKIRP 271_ FMKAH 276_ LNRDK 281_ DKELL 286_ KLTQY 291_ LKEIA 296_ KLDDF 301_ LDLNH 306_ KYWER 311_YLSKK
1: Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity (PubMed:21949367, PubMed:28539385). Recruited to the 19S regulatory particle of the 26S proteasome through its interaction with 19S component PSMD2/RPN1 (PubMed:28539385). Once recruited, dephosphorylates 19S component PSMC2/RPT1 which impairs PSMC2 ATPase activity and disrupts 26S proteasome assembly (PubMed:28539385). Has also been reported to stimulate the proteolytic activity of the 26S proteasome (PubMed:32071216)