Palmitoyltransferase ZDHHC19 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 19) (DHHC-19)
1_MTLLT 6_ DATPL 11_ VKEPH 16_ PLPLV 21_ PRPWF 26_ LPSLF 31_ AAFNV 36_ VLLVF 41_ FSGLF 46_ FAFPC 51_ RWLAQ 56_ NGEWA 61_ FPVIT 66_ GSLFV 71_ LTFFS 76_ LVSLN 81_ FSDPG 86_ ILHQG 91_ SAEQG 96_ PLTVH 101_ VVWVN 106_ HGAFR 111_ LQWCP 116_ KCCFH 121_ RPPRT 126_ YHCPW 131_ CNICV 136_ EDFDH 141_ HCKWV 146_ NNCIG 151_ HRNFR 156_ FFMLL 161_ VLSLC 166_ LYSGA 171_ MLVTC 176_ LIFLV 181_ RTTHL 186_ PFSTD 191_ KAIAI 196_ VVAVS 201_ AAGLL 206_ VPLSL 211_ LLLIQ 216_ ALSVS 221_ SADRT 226_ YKGKC 231_ RHLQG 236_ YNPFD 241_ QGCAS 246_ NWYLT 251_ ICAPL 256_ GPKYM 261_ AEAVQ 266_ LQRVV 271_ GPDWT 276_ SMPNL 281_ HPPMS 286_ PSALN 291_ PPAPT 296_ SGSLQ 301_SREGT
1: Palmitoyltransferase that mediates palmitoylation oproteins, such as RRAS and SQSTM1 (PubMed:20074548, PubMed:37802024). Catalyzes palmitoylation of RRAS, leading to increased cell viability (PubMed:20074548). Acts as a positive regulator of autophagy by mediating palmitoylation of SQSTM1, promoting affinity between SQSTM1 and ATG8 proteins and recruitment of ubiquitinated cargo proteins to autophagosomes (PubMed:37802024)
2: (Microbial infection) Promotes Chikungunya virus (CHIKV) replication by mediating viral nsp1 palmitoylation