Kelch repeat and BTB domain-containing protein 7
1_MQSRE 6_ DVPRS 11_ RRLAS 16_ PRGGR 21_ RPKRI 26_ SKPSV 31_ SAFFT 36_ GPEEL 41_ KDTAH 46_ SAALL 51_ AQLKS 56_ FYDAR 61_ LLCDV 66_ TIEVV 71_ TPGSG 76_ PGTGR 81_ LFSCN 86_ RNVLA 91_ AACPY 96_ FKSMF 101_ TGGMY 106_ ESQQA 111_ SVTMH 116_ DVDAE 121_ SFEVL 126_ VDYCY 131_ TGRVS 136_ LSEAN 141_ VQRLY 146_ AASDM 151_ LQLEY 156_ VREAC 161_ ASFLA 166_ RRLDL 171_ TNCTA 176_ ILKFA 181_ DAFDH 186_ HKLRS 191_ QAQSY 196_ IAHNF 201_ KQLSR 206_ MGSIR 211_ EETLA 216_ DLTLA 221_ QLLAV 226_ LRLDS 231_ LDIES 236_ ERTVC 241_ HVAVQ 246_ WLEAA 251_ AKERG 256_ PSAAE 261_ VFKCV 266_ RWMHF 271_ TEEDQ 276_ DYLEG 281_ LLTKP 286_ IVKKY 291_ CLDVI 296_ EGALQ 301_ MRYGD 306_ LLYKS 311_ LVPVP 316_ NSSSS 321_ SSSSN 326_ SLVSA 331_ AENPP 336_ QRLGM 341_ CAKEM 346_ VIFFG 351_ HPRDP 356_ FLCYD 361_ PYSGD 366_ IYTMP 371_ SPLTS 376_ FAHTK 381_ TVTSS 386_ AVCVS 391_ PDHDI 396_ YLAAQ 401_ PRKDL 406_ WVYKP 411_ AQNSW 416_ QQLAD 421_ RLLCR 426_ EGMDV 431_ AYLNG 436_ YIYIL 441_ GGRDP 446_ ITGVK 451_ LKEVE 456_ CYSVQ 461_ RNQWA 466_ LVAPV 471_ PHSFY 476_ SFELI 481_ VVQNY 486_ LYAVN 491_ SKRML 496_ CYDPS 501_ HNMWL 506_ NCASL 511_ KRSDF 516_ QEACV 521_ FNDEI 526_ YCICD 531_ IPVMK 536_ VYNPA 541_ RGEWR 546_ RISNI 551_ PLDSE 556_ THNYQ 561_ IVNHD 566_ QKLLL 571_ ITSTT 576_ PQWKK 581_ NRVTV 586_ YEYDT 591_ REDQW 596_ INIGT 601_ MLGLL 606_ QFDSG 611_ FICLC 616_ ARVYP 621_ SCLEP 626_ GQSFI 631_ TEEDD 636_ ARSES 641_ STEWD 646_ LDGFS 651_ ELDSE 656_ SGSSS 661_ SFSDD 666_ EVWVQ 671_ VAPQR 676_NAQDQ
1: As part of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex functions as a substrate adapter for the RAC1 guanine exchange factor (GEF) TIAM1, mediating its 'Lys-48' ubiquitination and proteasomal degradation (PubMed:25684205). By controlling this ubiquitination, regulates RAC1 signal transduction and downstream biological processes including the organization of the cytoskeleton, cell migration and cell proliferation (PubMed:25684205). Ubiquitination of TIAM1 requires the membrane-associated protein GABARAP which may restrict locally the activity of the complex (PubMed:25684205)