tRNA-splicing endonuclease subunit Sen15 (SEN15 homolog) (HsSEN15) (tRNA-intron endonuclease Sen15)
1_MEERG 6_ DSEPT 11_ PGCSG 16_ LGPGG 21_ VRGFG 26_ DGGGA 31_ PSWAP 36_ EDAWM 41_ GTHPK 46_ YLEMM 51_ ELDIG 56_ DATQV 61_ YVAFL 66_ VYLDL 71_ MESKS 76_ WHEVN 81_ CVGLP 86_ ELQLI 91_ CLVGT 96_ EIEGE 101_ GLQTV 106_ VPTPI 111_ TASLS 116_ HNRIR 121_ EILKA 126_ SRKLQ 131_ GDPDL 136_ PMSFT 141_ LAIVE 146_ SDSTI 151_ VYYKL 156_ TDGFM 161_ LPDPQ 166_NISLR
1: Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini (PubMed:15109492, PubMed:27392077). There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events (PubMed:15109492)