Gamma-secretase subunit APH-1B (APH-1b) (Aph-1beta) (Presenilin-stabilization factor-like)
1_MTAAV 6_ FFGCA 11_ FIAFG 16_ PALAL 21_ YVFTI 26_ ATEPL 31_ RIIFL 36_ IAGAF 41_ FWLVS 46_ LLISS 51_ LVWFM 56_ ARVII 61_ DNKDG 66_ PTQKY 71_ LLIFG 76_ AFVSV 81_ YIQEM 86_ FRFAY 91_ YKLLK 96_ KASEG 101_ LKSIN 106_ PGETA 111_ PSMRL 116_ LAYVS 121_ GLGFG 126_ IMSGV 131_ FSFVN 136_ TLSDS 141_ LGPGT 146_ VGIHG 151_ DSPQF 156_ FLYSA 161_ FMTLV 166_ IILLH 171_ VFWGI 176_ VFFDG 181_ CEKKK 186_ WGILL 191_ IVLLT 196_ HLLVS 201_ AQTFI 206_ SSYYG 211_ INLAS 216_ AFIIL 221_ VLMGT 226_ WAFLA 231_ AGGSC 236_ RSLKL 241_ CLLCQ 246_ DKNFL 251_LYNQR
1: Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (amyloid-beta precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A