Intelectin-1 (ITLN-1) (Endothelial lectin HL-1) (Galactofuranose-binding lectin) (Intestinal lactoferrin receptor) (Omentin)
1_MNQLS 6_ FLLFL 11_ IATTR 16_ GWSTD 21_ EANTY 26_ FKEWT 31_ CSSSP 36_ SLPRS 41_ CKEIK 46_ DECPS 51_ AFDGL 56_ YFLRT 61_ ENGVI 66_ YQTFC 71_ DMTSG 76_ GGGWT 81_ LVASV 86_ HENDM 91_ RGKCT 96_ VGDRW 101_ SSQQG 106_ SKAVY 111_ PEGDG 116_ NWANY 121_ NTFGS 126_ AEAAT 131_ SDDYK 136_ NPGYY 141_ DIQAK 146_ DLGIW 151_ HVPNK 156_ SPMQH 161_ WRNSS 166_ LLRYR 171_ TDTGF 176_ LQTLG 181_ HNLFG 186_ IYQKY 191_ PVKYG 196_ EGKCW 201_ TDNGP 206_ VIPVV 211_ YDFGD 216_ AQKTA 221_ SYYSP 226_ YGQRE 231_ FTAGF 236_ VQFRV 241_ FNNER 246_ AANAL 251_ CAGMR 256_ VTGCN 261_ TEHHC 266_ IGGGG 271_ YFPEA 276_ SPQQC 281_ GDFSG 286_ FDWSG 291_ YGTHV 296_ GYSSS 301_ REITE 306_AAVLL
1: Lectin that specifically recognizes microbial carbohydrate chains in a calcium-dependent manner (PubMed:11313366, PubMed:26148048). Binds to microbial glycans that contain a terminal acyclic 1,2-diol moiety, including beta-linked D-galactofuranose (beta-Galf), D-phosphoglycerol-modified glycans, D-glycero-D-talo-oct-2-ulosonic acid (KO) and 3-deoxy-D-manno-oct-2-ulosonic acid (KDO) (PubMed:26148048). Binds to glycans from Gram-positive and Gram-negative bacteria, including K.pneumoniae, S.pneumoniae, Y.pestis, P.mirabilis and P.vulgaris (PubMed:26148048). Does not bind human glycans (PubMed:26148048). Probably plays a role in the defense system against microorganisms (Probable). May function as adipokine that has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes (PubMed:16531507). Increases AKT phosphorylation in the absence and presence of insulin (PubMed:16531507). May interact with lactoferrin/LTF and increase its uptake, and may thereby play a role in iron absorption (PubMed:11747454, PubMed:23921499)