E3 ubiquitin-protein ligase ZNRF4 (EC 2.3.2.27) (Nixin) (RING finger protein 204) (RING-type E3 ubiquitin transferase ZNRF4) (Zinc/RING finger protein 4)
1_MPLCR 6_ PEHLM 11_ PRASR 16_ VPVAA 21_ SLPLS 26_ HAVIP 31_ TQLPS 36_ RPGHR 41_ PPGRP 46_ RRCPK 51_ ASCLP 56_ PPVGP 61_ SSTQT 66_ AKRVT 71_ MGWPR 76_ PGRAL 81_ VAVKA 86_ LLVLS 91_ LLQVP 96_ AQAVV 101_ RAVLE 106_ DNSSS 111_ VDFAD 116_ LPALF 121_ GVPLA 126_ PEGIR 131_ GYLME 136_ VKPAN 141_ ACHPI 146_ EAPRL 151_ GNRSL 156_ GAIVL 161_ IRRYD 166_ CTFDL 171_ KVLNA 176_ QRAGF 181_ EAAIV 186_ HNVHS 191_ DDLVS 196_ MTHVY 201_ EDLRG 206_ QIAIP 211_ SVFVS 216_ EAASQ 221_ DLRVI 226_ LGCNK 231_ SAHAL 236_ LLPDD 241_ PPCHD 246_ LGCHP 251_ VLTVS 256_ WVLGC 261_ TLALV 266_ VSAFF 271_ VLNHL 276_ WLWAQ 281_ ACCSH 286_ RRPVK 291_ TSTCQ 296_ KAQVR 301_ TFTWH 306_ NDLCA 311_ ICLDE 316_ YEEGD 321_ QLKIL 326_ PCSHT 331_ YHCKC 336_ IDPWF 341_ SQAPR 346_ RSCPV 351_ CKQSV 356_ AATED 361_ SFDST 366_ TYSFR 371_ DEDPS 376_ LPGHR 381_ PPIWA 386_ IQVQL 391_ RSRRL 396_ ELLGR 401_ ASPHC 406_ HCSTT 411_ SLEAE 416_ YTTVS 421_SAPPE
1: E3 ubiquitin-protein ligase that acts as a negative regulator of NOD2 signaling by mediating ubiquitination and degradation of RIPK2 (PubMed:28656966). Also catalyzes ubiquitination and proteasomal degradation of CANX within the endoplasmic reticulum (PubMed:21205830). Could have a role in spermatogenesis (By similarity)