Pro-neuregulin-4, membrane-bound isoform (Pro-NRG4) [Cleaved into: Neuregulin-4 (NRG-4)]
1_MPTDH 6_ EEPCG 11_ PSHKS 16_ FCLNG 21_ GLCYV 26_ IPTIP 31_ SPFCR 36_ CVENY 41_ TGARC 46_ EEVFL 51_ PGSSI 56_ QTKSN 61_ LFEAF 66_ VALAV 71_ LVTLI 76_ IGAFY 81_ FLCRK 86_ GHFQR 91_ ASSVQ 96_ YDINL 101_ VETSS 106_TSAHH
1: Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors (By similarity)