Potassium voltage-gated channel subfamily E member 4 (MinK-related peptide 3) (Minimum potassium ion channel-related peptide 3) (Potassium channel subunit beta MiRP3)
1_MHFLT 6_ IYPNC 11_ SSGVV 16_ RAQSR 21_ TEQKN 26_ PLGLD 31_ DLGIQ 36_ NLGQT 41_ VSLAP 46_ AVEAA 51_ SMLKM 56_ EPLNS 61_ THPGT 66_ AASSS 71_ PLESR 76_ AAGGG 81_ SGNGN 86_ EYFYI 91_ LVVMS 96_ FYGIF 101_ LIGIM 106_ LGYMK 111_ SKRRE 116_ KKSSL 121_ LLLYK 126_ DEERL 131_ WGEAM 136_ KPLPV 141_ VSGLR 146_ SVQVP 151_ LMLNM 156_ LQESV 161_ APALS 166_ CTLCS 171_ MEGDS 176_ VSSES 181_ SSPDV 186_ HLTIQ 191_ EEGAD 196_ DELEE 201_ TSETP 206_ LNESS 211_ EGSSE 216_NIHQN
1: Ancillary protein that functions as a regulatory subunit of the voltage-gated potassium (Kv) channel complex composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits. KCNE4 beta subunit modulates the gating kinetics and enhances stability of the channel complex (PubMed:12096056, PubMed:19687231, PubMed:20533308, PubMed:27162025). Associates with KCNQ1/KVLTQ1 alpha subunit to inhibit potassium currents (PubMed:12096056, PubMed:19687231, PubMed:20533308, PubMed:27162025)
2: May inhibit KCNQ4-mediated potassium currents