Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 (Ankyrin-like protein 1) (Germ cell-specific ankyrin, SAM and basic leucine zipper domain-containing protein)
1_MAASA 6_ LRGLP 11_ VAGGG 16_ ESSES 21_ EDDGW 26_ EIGYL 31_ DRTSQ 36_ KLKRL 41_ LPIEE 46_ KKEKF 51_ KKAMT 56_ IGDVS 61_ LVQEL 66_ LDSGI 71_ SVDSN 76_ FQYGW 81_ TPLMY 86_ AASVA 91_ NAELV 96_ RVLLD 101_ RGANA 106_ SFEKD 111_ KQSIL 116_ ITACS 121_ AHGSE 126_ EQILK 131_ CVELL 136_ LSRNA 141_ DPNVA 146_ CRRLM 151_ TPIMY 156_ AARDG 161_ HTQVV 166_ ALLVA 171_ HGAEV 176_ NTQDE 181_ NGYTA 186_ LTWAA 191_ RQGHK 196_ NIVLK 201_ LLELG 206_ ANKML 211_ QTKDG 216_ KMPSE 221_ IAKRN 226_ KHHEI 231_ FNLLS 236_ FTLNP 241_ LEGKL 246_ QQLTK 251_ EDTIC 256_ KILTT 261_ DSDRE 266_ KDHIF 271_ SSYTA 276_ FGDLE 281_ VFLHG 286_ LGLEH 291_ MTDLL 296_ KERDI 301_ TLRHL 306_ LTMRE 311_ DEFTK 316_ NGITS 321_ KDQQK 326_ ILAAL 331_ KELQV 336_ EEIQF 341_ GELSE 346_ ETKLE 351_ ISGDE 356_ FLNFL 361_ LKLNK 366_ QCGHL 371_ ITAVQ 376_ NVITE 381_ LPVNS 386_ QKITL 391_ EWASP 396_ QNFTS 401_ VCEEL 406_ VNNVE 411_ DLSEK 416_ VCKLK 421_ DLIQK 426_ LQNER 431_ ENDPT 436_ HIQLR 441_ EEVST 446_ WNSRI 451_ LKRTA 456_ ITICG 461_ FGFLL 466_FICKL
1: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation (By similarity)