Protein spire homolog 2 (Spir-2)
1_MARAG 6_ SCGGA 11_ AAGAG 16_ RPEPW 21_ ELSLE 26_ EVLKA 31_ YEQPL 36_ NEEQA 41_ WAVCF 46_ QGCRG 51_ LRGSP 56_ GRRLR 61_ DTGDL 66_ LLRGD 71_ GSVGA 76_ REPEA 81_ AEPAT 86_ MVVPL 91_ ASSEA 96_ QTVQS 101_ LGFAI 106_ YRALD 111_ WGLDE 116_ SEERE 121_ LSPQL 126_ ERLID 131_ LMANN 136_ DSEDS 141_ GCGAA 146_ DEGYG 151_ GPEEE 156_ EEAEG 161_ VPRSV 166_ RTFAQ 171_ AMRLC 176_ AARLT 181_ DPRGA 186_ QAHYQ 191_ AVCRA 196_ LFVET 201_ LELRA 206_ FLARV 211_ REAKE 216_ MLQKL 221_ REDEP 226_ HLETP 231_ RAELD 236_ SLGHT 241_ DWARL 246_ WVQLM 251_ RELRR 256_ GVKLK 261_ KVQEQ 266_ EFNPL 271_ PTEFQ 276_ LTPFE 281_ MLMQD 286_ IRARN 291_ YKLRK 296_ VMVDG 301_ DIPPR 306_ VKKDA 311_ HELIL 316_ DFIRS 321_ RPPLK 326_ QVSER 331_ RLRPL 336_ PPKQR 341_ SLHEK 346_ ILEEI 351_ KQERR 356_ LRPVR 361_ GEGWA 366_ ARGFG 371_ SLPCI 376_ LNACS 381_ GDAKS 386_ TSCIN 391_ LSVTD 396_ AGGSA 401_ QRPRP 406_ RVLLK 411_ APTLA 416_ EMEEM 421_ NTSEE 426_ EESPC 431_ GEVTL 436_ KRDRS 441_ FSEHD 446_ LAQLR 451_ SEVAS 456_ GLQSA 461_ THPPG 466_ GTEPP 471_ RPRAG 476_ SAHVW 481_ RPGSR 486_ DQGTC 491_ PASVS 496_ DPSHP 501_ LLSNR 506_ GSSGD 511_ RPEAS 516_ MTPDA 521_ KHLWL 526_ EFSHP 531_ VESLA 536_ LTVEE 541_ VMDVR 546_ RVLVK 551_ AEMEK 556_ FLQNK 561_ ELFSS 566_ LKKGK 571_ ICCCC 576_ RAKFP 581_ LFSWP 586_ PSCLF 591_ CKRAV 596_ CTSCS 601_ IKMKM 606_ PSKKF 611_ GHIPV 616_ YTLGF 621_ ESPQR 626_ VSAAK 631_ TAPIQ 636_ RRDIF 641_ QSLQG 646_ PQWQS 651_ VEEAF 656_ PHIYS 661_ HGCVL 666_ KDVCS 671_ ECTSF 676_ VADVV 681_ RSSRK 686_ SVDVL 691_ NTTPR 696_ RSRQT 701_ QSLYI 706_PNTRT
1: Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament (PubMed:21620703). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (By similarity). Required for asymmetric spindle positioning and asymmetric cell division during meiosis (PubMed:21620703). Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis (PubMed:21620703). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480)