Gene name: HPSE2

Uniprot entry:

Q8WWQ2

Protein names:

Inactive heparanase-2 (Hpa2)

Protein sequence:

1_MRVLC 6_ AFPEA 11_ MPSSN 16_ SRPPA 21_ CLAPG 26_ ALYLA 31_ LLLHL 36_ SLSSQ 41_ AGDRR 46_ PLPVD 51_ RAAGL 56_ KEKTL 61_ ILLDV 66_ STKNP 71_ VRTVN 76_ ENFLS 81_ LQLDP 86_ SIIHD 91_ GWLDF 96_ LSSKR 101_ LVTLA 106_ RGLSP 111_ AFLRF 116_ GGKRT 121_ DFLQF 126_ QNLRN 131_ PAKSR 136_ GGPGP 141_ DYYLK 146_ NYEDD 151_ IVRSD 156_ VALDK 161_ QKGCK 166_ IAQHP 171_ DVMLE 176_ LQREK 181_ AAQMH 186_ LVLLK 191_ EQFSN 196_ TYSNL 201_ ILTAR 206_ SLDKL 211_ YNFAD 216_ CSGLH 221_ LIFAL 226_ NALRR 231_ NPNNS 236_ WNSSS 241_ ALSLL 246_ KYSAS 251_ KKYNI 256_ SWELG 261_ NEPNN 266_ YRTMH 271_ GRAVN 276_ GSQLG 281_ KDYIQ 286_ LKSLL 291_ QPIRI 296_ YSRAS 301_ LYGPN 306_ IGRPR 311_ KNVIA 316_ LLDGF 321_ MKVAG 326_ STVDA 331_ VTWQH 336_ CYIDG 341_ RVVKV 346_ MDFLK 351_ TRLLD 356_ TLSDQ 361_ IRKIQ 366_ KVVNT 371_ YTPGK 376_ KIWLE 381_ GVVTT 386_ SAGGT 391_ NNLSD 396_ SYAAG 401_ FLWLN 406_ TLGML 411_ ANQGI 416_ DVVIR 421_ HSFFD 426_ HGYNH 431_ LVDQN 436_ FNPLP 441_ DYWLS 446_ LLYKR 451_ LIGPK 456_ VLAVH 461_ VAGLQ 466_ RKPRP 471_ GRVIR 476_ DKLRI 481_ YAHCT 486_ NHHNH 491_ NYVRG 496_ SITLF 501_ IINLH 506_ RSRKK 511_ IKLAG 516_ TLRDK 521_ LVHQY 526_ LLQPY 531_ GQEGL 536_ KSKSV 541_ QLNGQ 546_ PLVMV 551_ DDGTL 556_ PELKP 561_ RPLRA 566_ GRTLV 571_ IPPVT 576_ MGFYV 581_ VKNVN 586_ALACR

Protein annotations

Protein functions:

1: Binds heparin and heparan sulfate with high affinity, but lacks heparanase activity. Inhibits HPSE, possibly by competing for its substrates (in vitro)