Sialidase-4 (EC 3.2.1.18) (N-acetyl-alpha-neuraminidase 4)
1_MGVPR 6_ TPSRT 11_ VLFER 16_ ERTGL 21_ TYRVP 26_ SLLPV 31_ PPGPT 36_ LLAFV 41_ EQRLS 46_ PDDSH 51_ AHRLV 56_ LRRGT 61_ LAGGS 66_ VRWGA 71_ LHVLG 76_ TAALA 81_ EHRSM 86_ NPCPV 91_ HDAGT 96_ GTVFL 101_ FFIAV 106_ LGHTP 111_ EAVQI 116_ ATGRN 121_ AARLC 126_ CVASR 131_ DAGLS 136_ WGSAR 141_ DLTEE 146_ AIGGA 151_ VQDWA 156_ TFAVG 161_ PGHGV 166_ QLPSG 171_ RLLVP 176_ AYTYR 181_ VDRRE 186_ CFGKI 191_ CRTSP 196_ HSFAF 201_ YSDDH 206_ GRTWR 211_ CGGLV 216_ PNLRS 221_ GECQL 226_ AAVDG 231_ GQAGS 236_ FLYCN 241_ ARSPL 246_ GSRVQ 251_ ALSTD 256_ EGTSF 261_ LPAER 266_ VASLP 271_ ETAWG 276_ CQGSI 281_ VGFPA 286_ PAPNR 291_ PRDDS 296_ WSVGP 301_ GSPLQ 306_ PPLLG 311_ PGVHE 316_ PPEEA 321_ AVDPR 326_ GGQVP 331_ GGPFS 336_ RLQPR 341_ GDGPR 346_ QPGPR 351_ PGVSG 356_ DVGSW 361_ TLALP 366_ MPFAA 371_ PPQSP 376_ TWLLY 381_ SHPVG 386_ RRARL 391_ HMGIR 396_ LSQSP 401_ LDPRS 406_ WTEPW 411_ VIYEG 416_ PSGYS 421_ DLASI 426_ GPAPE 431_ GGLVF 436_ ACLYE 441_ SGART 446_ SYDEI 451_ SFCTF 456_ SLREV 461_ LENVP 466_ ASPKP 471_ PNLGD 476_KPRGC
1: Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Efficiently hydrolyzes gangliosides including alpha-(2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3 (PubMed:15213228, PubMed:15847605, PubMed:21521691). Hydrolyzes poly-alpha-(2->8)-sialylated neural cell adhesion molecule NCAM1 likely at growth cones, suppressing neurite outgrowth in hippocampal neurons (By similarity). May desialylate sialyl Lewis A and X antigens at the cell surface, down-regulating these glycan epitopes recognized by SELE/E selectin in the initiation of cell adhesion and extravasation (PubMed:21521691). Has sialidase activity toward mucin, fetuin and sialyllactose (PubMed:15847605)