Reticulon-4-interacting protein 1, mitochondrial (NOGO-interacting mitochondrial protein)
1_MEFLK 6_ TCVLR 11_ RNACT 16_ AVCFW 21_ RSKVV 26_ QKPSV 31_ RRIST 36_ TSPRS 41_ TVMPA 46_ WVIDK 51_ YGKNE 56_ VLRFT 61_ QNMMM 66_ PIIHY 71_ PNEVI 76_ VKVHA 81_ ASVNP 86_ IDVNM 91_ RSGYG 96_ ATALN 101_ MKRDP 106_ LHVKI 111_ KGEEF 116_ PLTLG 121_ RDVSG 126_ VVMEC 131_ GLDVK 136_ YFKPG 141_ DEVWA 146_ AVPPW 151_ KQGTL 156_ SEFVV 161_ VSGNE 166_ VSHKP 171_ KSLTH 176_ TQAAS 181_ LPYVA 186_ LTAWS 191_ AINKV 196_ GGLND 201_ KNCTG 206_ KRVLI 211_ LGASG 216_ GVGTF 221_ AIQVM 226_ KAWDA 231_ HVTAV 236_ CSQDA 241_ SELVR 246_ KLGAD 251_ DVIDY 256_ KSGSV 261_ EEQLK 266_ SLKPF 271_ DFILD 276_ NVGGS 281_ TETWA 286_ PDFLK 291_ KWSGA 296_ TYVTL 301_ VTPFL 306_ LNMDR 311_ LGIAD 316_ GMLQT 321_ GVTVG 326_ SKALK 331_ HFWKG 336_ VHYRW 341_ AFFMA 346_ SGPCL 351_ DDIAE 356_ LVDAG 361_ KIRPV 366_ IEQTF 371_ PFSKV 376_ PEAFL 381_ KVERG 386_ HARGK 391_TVINV
1: NAD(P)H oxidoreductase involved in the ubiquinone biosynthetic pathway (PubMed:37884807). Required for the O-methyltransferase activity of COQ3 (PubMed:37884807). Able to catalyze the oxidoreduction of 3-demethylubiquinone into 3-demethylubiquinol in vitro (PubMed:37884807). However, it is unclear if 3-demethylubiquinone constitutes a substrate in vivo (PubMed:37884807). May also play a role in the regulation of retinal ganglion cell (RGC) neurite outgrowth, and hence in the development of the inner retina and optic nerve (By similarity). Appears to be a potent inhibitor of regeneration following spinal cord injury (By similarity)