Ras association domain-containing protein 5 (New ras effector 1) (Regulator for cell adhesion and polarization enriched in lymphoid tissues) (RAPL)
1_MAMAS 6_ PAIGQ 11_ RPYPL 16_ LLDPE 21_ PPRYL 26_ QSLSG 31_ PELPP 36_ PPPDR 41_ SSRLC 46_ VPAPL 51_ STAPG 56_ AREGR 61_ SARRA 66_ ARGNL 71_ EPPPR 76_ ASRPA 81_ RPLRP 86_ GLQQR 91_ LRRRP 96_ GAPRP 101_ RDVRS 106_ IFEQP 111_ QDPRV 116_ PAERG 121_ EGHCF 126_ AELVL 131_ PGGPG 136_ WCDLC 141_ GREVL 146_ RQALR 151_ CTNCK 156_ FTCHP 161_ ECRSL 166_ IQLDC 171_ SQQEG 176_ LSRDR 181_ PSPES 186_ TLTVT 191_ FSQNV 196_ CKPVE 201_ ETQRP 206_ PTLQE 211_ IKQKI 216_ DSYNT 221_ REKNC 226_ LGMKL 231_ SEDGT 236_ YTGFI 241_ KVHLK 246_ LRRPV 251_ TVPAG 256_ IRPQS 261_ IYDAI 266_ KEVNL 271_ AATTD 276_ KRTSF 281_ YLPLD 286_ AIKQL 291_ HISST 296_ TTVSE 301_ VIQGL 306_ LKKFM 311_ VVDNP 316_ QKFAL 321_ FKRIH 326_ KDGQV 331_ LFQKL 336_ SIADR 341_ PLYLR 346_ LLAGP 351_ DTEVL 356_ SFVLK 361_ ENETG 366_ EVEWD 371_ AFSIP 376_ ELQNF 381_ LTILE 386_ KEEQD 391_ KIQQV 396_ QKKYD 401_ KFRQK 406_ LEEAL 411_RESQG
1: Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis