Sodium/myo-inositol cotransporter 2 (Na(+)/myo-inositol cotransporter 2) (Sodium-dependent glucose cotransporter) (Sodium/glucose cotransporter KST1) (Sodium/myo-inositol transporter 2) (SMIT2) (Solute carrier family 5 member 11)
1_MESGT 6_ SSPQP 11_ PQLDP 16_ LDAFP 21_ QKGLE 26_ PGDIA 31_ VLVLY 36_ FLFVL 41_ AVGLW 46_ STVKT 51_ KRDTV 56_ KGYFL 61_ AGGDM 66_ VWWPV 71_ GASLF 76_ ASNVG 81_ SGHFI 86_ GLAGS 91_ GAATG 96_ ISVSA 101_ YELNG 106_ LFSVL 111_ MLAWI 116_ FLPIY 121_ IAGQV 126_ TTMPE 131_ YLRKR 136_ FGGIR 141_ IPIIL 146_ AVLYL 151_ FIYIF 156_ TKISV 161_ DMYAG 166_ AIFIQ 171_ QSLHL 176_ DLYLA 181_ IVGLL 186_ AITAV 191_ YTVAG 196_ GLAAV 201_ IYTDA 206_ LQTLI 211_ MLIGA 216_ LTLMG 221_ YSFAA 226_ VGGME 231_ GLKEK 236_ YFLAL 241_ ASNRS 246_ ENSSC 251_ GLPRE 256_ DAFHI 261_ FRDPL 266_ TSDLP 271_ WPGVL 276_ FGMSI 281_ PSLWY 286_ WCTDQ 291_ VIVQR 296_ TLAAK 301_ NLSHA 306_ KGGAL 311_ MAAYL 316_ KVLPL 321_ FIMVF 326_ PGMVS 331_ RILFP 336_ DQVAC 341_ ADPEI 346_ CQKIC 351_ SNPSG 356_ CSDIA 361_ YPKLV 366_ LELLP 371_ TGLRG 376_ LMMAV 381_ MVAAL 386_ MSSLT 391_ SIFNS 396_ ASTIF 401_ TMDLW 406_ NHLRP 411_ RASEK 416_ ELMIV 421_ GRVFV 426_ LLLVL 431_ VSILW 436_ IPVVQ 441_ ASQGG 446_ QLFIY 451_ IQSIS 456_ SYLQP 461_ PVAVV 466_ FIMGC 471_ FWKRT 476_ NEKGA 481_ FWGLI 486_ SGLLL 491_ GLVRL 496_ VLDFI 501_ YVQPR 506_ CDQPD 511_ ERPVL 516_ VKSIH 521_ YLYFS 526_ MILST 531_ VTLIT 536_ VSTVS 541_ WFTEP 546_ PSKEM 551_ VSHLT 556_ WFTRH 561_ DPVVQ 566_ KEQAP 571_ PAAPL 576_ SLTLS 581_ QNGMP 586_ EASSS 591_ SSVQF 596_ EMVQE 601_ NTSKT 606_ HSCDM 611_ TPKQS 616_ KVVKA 621_ ILWLC 626_ GIQEK 631_ GKEEL 636_ PARAE 641_ AIIVS 646_ LEENP 651_ LVKTL 656_ LDVNL 661_ IFCVS 666_CAIFI
1: Involved in the sodium-dependent cotransport of myo-inositol (MI) with a Na(+):MI stoichiometry of 2:1 (PubMed:15172003, PubMed:19032932). Exclusively responsible for apical MI transport and absorption in intestine (By similarity). Can also transport D-chiro-inositol (DCI) but not L-fucose (PubMed:15172003, PubMed:19032932). Exhibits stereospecific cotransport of both D-glucose and D-xylose (By similarity). May induce apoptosis through the TNF-alpha, PDCD1 pathway (PubMed:15172003, PubMed:18069935). May play a role in the regulation of MI concentration in serum, involving reabsorption in at least the proximal tubule of the kidney (By similarity)