Lipase member H (LIPH) (EC 3.1.1.-) (LPD lipase-related protein) (Membrane-associated phosphatidic acid-selective phospholipase A1-alpha) (mPA-PLA1 alpha) (Phospholipase A1 member B)
1_MLRFY 6_ LFISL 11_ LCLSR 16_ SDAEE 21_ TCPSF 26_ TRLSF 31_ HSAVV 36_ GTGLN 41_ VRLML 46_ YTRKN 51_ LTCAQ 56_ TINSS 61_ AFGNL 66_ NVTKK 71_ TTFIV 76_ HGFRP 81_ TGSPP 86_ VWMDD 91_ LVKGL 96_ LSVED 101_ MNVVV 106_ VDWNR 111_ GATTL 116_ IYTHA 121_ SSKTR 126_ KVAMV 131_ LKEFI 136_ DQMLA 141_ EGASL 146_ DDIYM 151_ IGVSL 156_ GAHIS 161_ GFVGE 166_ MYDGW 171_ LGRIT 176_ GLDPA 181_ GPLFN 186_ GKPHQ 191_ DRLDP 196_ SDAQF 201_ VDVIH 206_ SDTDA 211_ LGYKE 216_ PLGNI 221_ DFYPN 226_ GGLDQ 231_ PGCPK 236_ TILGG 241_ FQYFK 246_ CDHQR 251_ SVYLY 256_ LSSLR 261_ ESCTI 266_ TAYPC 271_ DSYQD 276_ YRNGK 281_ CVSCG 286_ TSQKE 291_ SCPLL 296_ GYYAD 301_ NWKDH 306_ LRGKD 311_ PPMTK 316_ AFFDT 321_ AEESP 326_ FCMYH 331_ YFVDI 336_ ITWNK 341_ NVRRG 346_ DITIK 351_ LRDKA 356_ GNTTE 361_ SKINH 366_ EPTTF 371_ QKYHQ 376_ VSLLA 381_ RFNQD 386_ LDKVA 391_ AISLM 396_ FSTGS 401_ LIGPR 406_ YKLRI 411_ LRMKL 416_ RSLAH 421_ PERPQ 426_ LCRYD 431_ LVLME 436_ NVETV 441_ FQPIL 446_CPELQ
1: Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG)