Insulin-like growth factor-binding protein-like 1 (IGFBP-related protein 10) (Insulin-like growth factor-binding-related protein 4) (IGFBP-rP4)
1_MPRLS 6_ LLLPL 11_ LLLLL 16_ LPLLP 21_ PLSPS 26_ LGIRD 31_ VGGRR 36_ PKCGP 41_ CRPEG 46_ CPAPA 51_ PCPAP 56_ GISAL 61_ DECGC 66_ CARCL 71_ GAEGA 76_ SCGGR 81_ AGGRC 86_ GPGLV 91_ CASQA 96_ AGAAP 101_ EGTGL 106_ CVCAQ 111_ RGTVC 116_ GSDGR 121_ SYPSV 126_ CALRL 131_ RARHT 136_ PRAHP 141_ GHLHK 146_ ARDGP 151_ CEFAP 156_ VVVVP 161_ PRSVH 166_ NVTGA 171_ QVGLS 176_ CEVRA 181_ VPTPV 186_ ITWRK 191_ VTKSP 196_ EGTQA 201_ LEELP 206_ GDHVN 211_ IAVQV 216_ RGGPS 221_ DHEAT 226_ AWILI 231_ NPLRK 236_ EDEGV 241_ YQCHA 246_ ANMVG 251_ EAESH 256_ STVTV 261_ LDLSK 266_ YRSFH 271_FPAPD
1: IGF-binding proteins prolong the half-life of IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs in cell culture. They alter the interaction of IGFs with their cell surface receptors (By similarity). May be a putative tumor suppressor protein