Negative elongation factor B (NELF-B) (Cofactor of BRCA1)
1_MFAGL 6_ QDLGV 11_ ANGED 16_ LKETL 21_ TNCTE 26_ PLKAI 31_ EQFQT 36_ ENGVL 41_ LPSLQ 46_ SALPF 51_ LDLHG 56_ TPRLE 61_ FHQSV 66_ FDELR 71_ DKLLE 76_ RVSAI 81_ ASEGK 86_ AEERY 91_ KKLED 96_ LLEKS 101_ FSLVK 106_ MPSLQ 111_ PVVMC 116_ VMKHL 121_ PKVPE 126_ KKLKL 131_ VMADK 136_ ELYRA 141_ CAVEV 146_ KRQIW 151_ QDNQA 156_ LFGDE 161_ VSPLL 166_ KQYIL 171_ EKESA 176_ LFSTE 181_ LSVLH 186_ NFFSP 191_ SPKTR 196_ RQGEV 201_ VQRLT 206_ RMVGK 211_ NVKLY 216_ DMVLQ 221_ FLRTL 226_ FLRTR 231_ NVHYC 236_ TLRAE 241_ LLMSL 246_ HDLDV 251_ GEICT 256_ VDPCH 261_ KFTWC 266_ LDACI 271_ RERFV 276_ DSKRA 281_ RELQG 286_ FLDGV 291_ KKGQE 296_ QVLGD 301_ LSMIL 306_ CDPFA 311_ INTLA 316_ LSTVR 321_ HLQEL 326_ VGQET 331_ LPRDS 336_ PDLLL 341_ LLRLL 346_ ALGQG 351_ AWDMI 356_ DSQVF 361_ KEPKM 366_ EVELI 371_ TRFLP 376_ MLMSF 381_ LVDDY 386_ TFNVD 391_ QKLPA 396_ EEKAP 401_ VSYPN 406_ TLPES 411_ FTKFL 416_ QEQRM 421_ ACEVG 426_ LYYVL 431_ HITKQ 436_ RNKNA 441_ LLRLL 446_ PGLVE 451_ TFGDL 456_ AFGDI 461_ FLHLL 466_ TGNLA 471_ LLADE 476_ FALED 481_ FCSSL 486_ FDGFF 491_ LTASP 496_ RKENV 501_ HRHAL 506_ RLLIH 511_ LHPRV 516_ APSKL 521_ EALQK 526_ ALEPT 531_ GQSGE 536_ AVKEL 541_ YSQLG 546_ EKLEQ 551_ LDHRK 556_ PSPAQ 561_ AAETP 566_ ALELP 571_LPSVP
1: Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (PubMed:12612062). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (PubMed:10199401). May be able to induce chromatin unfolding (PubMed:11739404). Essential for early embryogenesis; plays an important role in maintaining the undifferentiated state of embryonic stem cells (ESCs) by preventing unscheduled expression of developmental genes (By similarity). Plays a key role in establishing the responsiveness of stem cells to developmental cues; facilitates plasticity and cell fate commitment in ESCs by establishing the appropriate expression level of signaling molecules (By similarity). Supports the transcription of genes involved in energy metabolism in cardiomyocytes; facilitates the association of transcription initiation factors with the promoters of the metabolism-related genes (By similarity)
2: (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II (PubMed:23884411). In vitro, binds weakly to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1 (PubMed:23884411)