Paraspeckle component 1 (Paraspeckle protein 1)
1_MMLRG 6_ NLKQV 11_ RIEKN 16_ PARLR 21_ ALESA 26_ VGESE 31_ PAAAA 36_ AMALA 41_ LAGEP 46_ APPAP 51_ APPED 56_ HPDEE 61_ MGFTI 66_ DIKSF 71_ LKPGE 76_ KTYTQ 81_ RCRLF 86_ VGNLP 91_ TDITE 96_ EDFKR 101_ LFERY 106_ GEPSE 111_ VFINR 116_ DRGFG 121_ FIRLE 126_ SRTLA 131_ EIAKA 136_ ELDGT 141_ ILKSR 146_ PLRIR 151_ FATHG 156_ AALTV 161_ KNLSP 166_ VVSNE 171_ LLEQA 176_ FSQFG 181_ PVEKA 186_ VVVVD 191_ DRGRA 196_ TGKGF 201_ VEFAA 206_ KPPAR 211_ KALER 216_ CGDGA 221_ FLLTT 226_ TPRPV 231_ IVEPM 236_ EQFDD 241_ EDGLP 246_ EKLMQ 251_ KTQQY 256_ HKERE 261_ QPPRF 266_ AQPGT 271_ FEFEY 276_ ASRWK 281_ ALDEM 286_ EKQQR 291_ EQVDR 296_ NIREA 301_ KEKLE 306_ AEMEA 311_ ARHEH 316_ QLMLM 321_ RQDLM 326_ RRQEE 331_ LRRLE 336_ ELRNQ 341_ ELQKR 346_ KQIQL 351_ RHEEE 356_ HRRRE 361_ EEMIR 366_ HREQE 371_ ELRRQ 376_ QEGFK 381_ PNYME 386_ NREQE 391_ MRMGD 396_ MGPRG 401_ AINMG 406_ DAFSP 411_ APAGN 416_ QGPPP 421_ MMGMN 426_ MNNRA 431_ TIPGP 436_ PMGPG 441_ PAMGP 446_ EGAAN 451_ MGTPM 456_ MPDNG 461_ AVHND 466_ RFPQG 471_ PPSQM 476_ GSPMG 481_ SRTGS 486_ ETPQA 491_ PMSGV 496_ GPVSG 501_ GPGGF 506_ GRGSQ 511_ GGNFE 516_GPNKR
1: RNA-binding protein required for the formation of nuclear paraspeckles (PubMed:22416126). Binds to poly(A), poly(G) and poly(U) RNA homopolymers (PubMed:22416126). Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line (By similarity). Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728)