Atlastin-1 (EC 3.6.5.-) (Brain-specific GTP-binding protein) (GTP-binding protein 3) (GBP-3) (hGBP3) (Guanine nucleotide-binding protein 3) (Spastic paraplegia 3 protein A)
1_MAKNR 6_ RDRNS 11_ WGGFS 16_ EKTYE 21_ WSSEE 26_ EEPVK 31_ KAGPV 36_ QVLIV 41_ KDDHS 46_ FELDE 51_ TALNR 56_ ILLSE 61_ AVRDK 66_ EVVAV 71_ SVAGA 76_ FRKGK 81_ SFLMD 86_ FMLRY 91_ MYNQE 96_ SVDWV 101_ GDYNE 106_ PLTGF 111_ SWRGG 116_ SERET 121_ TGIQI 126_ WSEIF 131_ LINKP 136_ DGKKV 141_ AVLLM 146_ DTQGT 151_ FDSQS 156_ TLRDS 161_ ATVFA 166_ LSTMI 171_ SSIQV 176_ YNLSQ 181_ NVQED 186_ DLQHL 191_ QLFTE 196_ YGRLA 201_ MEETF 206_ LKPFQ 211_ SLIFL 216_ VRDWS 221_ FPYEF 226_ SYGAD 231_ GGAKF 236_ LEKRL 241_ KVSGN 246_ QHEEL 251_ QNVRK 256_ HIHSC 261_ FTNIS 266_ CFLLP 271_ HPGLK 276_ VATNP 281_ NFDGK 286_ LKEID 291_ DEFIK 296_ NLKIL 301_ IPWLL 306_ SPESL 311_ DIKEI 316_ NGNKI 321_ TCRGL 326_ VEYFK 331_ AYIKI 336_ YQGEE 341_ LPHPK 346_ SMLQA 351_ TAEAN 356_ NLAAV 361_ ATAKD 366_ TYNKK 371_ MEEIC 376_ GGDKP 381_ FLAPN 386_ DLQTK 391_ HLQLK 396_ EESVK 401_ LFRGV 406_ KKMGG 411_ EEFSR 416_ RYLQQ 421_ LESEI 426_ DELYI 431_ QYIKH 436_ NDSKN 441_ IFHAA 446_ RTPAT 451_ LFVVI 456_ FITYV 461_ IAGVT 466_ GFIGL 471_ DIIAS 476_ LCNMI 481_ MGLTL 486_ ITLCT 491_ WAYIR 496_ YSGEY 501_ RELGA 506_ VIDQV 511_ AAALW 516_ DQGST 521_ NEALY 526_ KLYSA 531_ AATHR 536_ HLYHQ 541_ AFPTP 546_ KSEST 551_EQSEK
1: Atlastin-1 (ATL1) is a membrane-anchored GTPase that mediates the GTP-dependent fusion of endoplasmic reticulum (ER) membranes, maintaining the continuous ER network. It facilitates the formation of three-way junctions where ER tubules intersect (PubMed:14506257, PubMed:18270207, PubMed:19665976, PubMed:27619977, PubMed:34817557, PubMed:38509071). Two atlastin-1 on neighboring ER tubules bind GTP and form loose homodimers through the GB1/RHD3-type G domains and 3HB regions. Upon GTP hydrolysis, the 3HB regions tighten, pulling the membranes together to drive their fusion. After fusion, the homodimer disassembles upon release of inorganic phosphate (Pi). Subsequently, GDP dissociates, resetting the monomers to a conformation ready for a new fusion cycle (PubMed:14506257, PubMed:21220294, PubMed:21368113, PubMed:23334294, PubMed:38509071). May also regulate more or less directly Golgi biogenesis (PubMed:17321752). Indirectly regulates axonal development (By similarity)