Radical S-adenosyl methionine domain-containing protein 2 (EC 4.2.-.-) (Cytomegalovirus-induced gene 5 protein) (Viperin) (Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible)
1_MWVLT 6_ PAAFA 11_ GKLLS 16_ VFRQP 21_ LSSLW 26_ RSLVP 31_ LFCWL 36_ RATFW 41_ LLATK 46_ RRKQQ 51_ LVLRG 56_ PDETK 61_ EEEED 66_ PPLPT 71_ TPTSV 76_ NYHFT 81_ RQCNY 86_ KCGFC 91_ FHTAK 96_ TSFVL 101_ PLEEA 106_ KRGLL 111_ LLKEA 116_ GMEKI 121_ NFSGG 126_ EPFLQ 131_ DRGEY 136_ LGKLV 141_ RFCKV 146_ ELRLP 151_ SVSIV 156_ SNGSL 161_ IRERW 166_ FQNYG 171_ EYLDI 176_ LAISC 181_ DSFDE 186_ EVNVL 191_ IGRGQ 196_ GKKNH 201_ VENLQ 206_ KLRRW 211_ CRDYR 216_ VAFKI 221_ NSVIN 226_ RFNVE 231_ EDMTE 236_ QIKAL 241_ NPVRW 246_ KVFQC 251_ LLIEG 256_ ENCGE 261_ DALRE 266_ AERFV 271_ IGDEE 276_ FERFL 281_ ERHKE 286_ VSCLV 291_ PESNQ 296_ KMKDS 301_ YLILD 306_ EYMRF 311_ LNCRK 316_ GRKDP 321_ SKSIL 326_ DVGVE 331_ EAIKF 336_ SGFDE 341_ KMFLK 346_ RGGKY 351_ IWSKA 356_DLKLD
1: Interferon-inducible antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon (PubMed:31812350). Catalyzes the conversion of cytidine triphosphate (CTP) to 3'-deoxy-3',4'-didehydro-CTP (ddhCTP) via a SAM-dependent radical mechanism (PubMed:29925952, PubMed:30872404). In turn, ddhCTP acts as a chain terminator for the RNA-dependent RNA polymerases from multiple viruses and directly inhibits viral replication (PubMed:29925952). Therefore, inhibits a wide range of DNA and RNA viruses, including human cytomegalovirus (HCMV), hepatitis C virus (HCV), west Nile virus (WNV), dengue virus, sindbis virus, influenza A virus, sendai virus, vesicular stomatitis virus (VSV), zika virus, and human immunodeficiency virus (HIV-1) (PubMed:29925952, PubMed:30587778, PubMed:30934824, PubMed:31921110). Also promotes TLR7 and TLR9-dependent production of IFN-beta production in plasmacytoid dendritic cells (pDCs) by facilitating 'Lys-63'-linked ubiquitination of IRAK1 by TRAF6 (PubMed:30872404). Plays a role in CD4+ T-cells activation and differentiation. Facilitates T-cell receptor (TCR)-mediated GATA3 activation and optimal T-helper 2 (Th2) cytokine production by modulating NFKB1 and JUNB activities. Can inhibit secretion of soluble proteins