MAP kinase-activating death domain protein (Differentially expressed in normal and neoplastic cells) (Insulinoma glucagonoma clone 20) (Rab3 GDP/GTP exchange factor) (RabGEF) (Rab3 GDP/GTP exchange protein) (Rab3GEP)
1_MVQKK 6_ KFCPR 11_ LLDYL 16_ VIVGA 21_ RHPSS 26_ DSVAQ 31_ TPELL 36_ RRYPL 41_ EDHTE 46_ FPLPP 51_ DVVFF 56_ CQPEG 61_ CLSVR 66_ QRRMS 71_ LRDDT 76_ SFVFT 81_ LTDKD 86_ TGVTR 91_ YGICV 96_ NFYRS 101_ FQKRI 106_ SKEKG 111_ EGGAG 116_ SRGKE 121_ GTHAT 126_ CASEE 131_ GGTES 136_ SESGS 141_ SLQPL 146_ SADST 151_ PDVNQ 156_ SPRGK 161_ RRAKA 166_ GSRSR 171_ NSTLT 176_ SLCVL 181_ SHYPF 186_ FSTFR 191_ ECLYT 196_ LKRLV 201_ DCCSE 206_ RLLGK 211_ KLGIP 216_ RGVQR 221_ DTMWR 226_ IFTGS 231_ LLVEE 236_ KSSAL 241_ LHDLR 246_ EIEAW 251_ IYRLL 256_ RSPVP 261_ VSGQK 266_ RVDIE 271_ VLPQE 276_ LQPAL 281_ TFALP 286_ DPSRF 291_ TLVDF 296_ PLHLP 301_ LELLG 306_ VDACL 311_ QVLTC 316_ ILLEH 321_ KVVLQ 326_ SRDYN 331_ ALSMS 336_ VMAFV 341_ AMIYP 346_ LEYMF 351_ PVIPL 356_ LPTCM 361_ ASAEQ 366_ LLLAP 371_ TPYII 376_ GVPAS 381_ FFLYK 386_ LDFKM 391_ PDDVW 396_ LVDLD 401_ SNRVI 406_ APTNA 411_ EVLPI 416_ LPEPE 421_ SLELK 426_ KHLKQ 431_ ALASM 436_ SLNTQ 441_ PILNL 446_ EKFHE 451_ GQEIP 456_ LLLGR 461_ PSNDL 466_ QSTPS 471_ TEFNP 476_ LIYGN 481_ DVDSV 486_ DVATR 491_ VAMVR 496_ FFNSA 501_ NVLQG 506_ FQMHT 511_ RTLRL 516_ FPRPV 521_ VAFQA 526_ GSFLA 531_ SRPRQ 536_ TPFAE 541_ KLART 546_ QAVEY 551_ FGEWI 556_ LNPTN 561_ YAFQR 566_ IHNNM 571_ FDPAL 576_ IGDKP 581_ KWYAH 586_ QLQPI 591_ HYRVY 596_ DSNSQ 601_ LAEAL 606_ SVPPE 611_ RDSDS 616_ EPTDD 621_ SGSDS 626_ MDYDD 631_ SSSSY 636_ SSLGD 641_ FVSEM 646_ MKCDI 651_ NGDTP 656_ NVDPL 661_ THAAL 666_ GDASE 671_ VEIDE 676_ LQNQK 681_ EAEEP 686_ GPDSE 691_ NSQEN 696_ PPLRS 701_ SSSTT 706_ ASSSP 711_ STVIH 716_ GANSE 721_ PADST 726_ EMDDK 731_ AAVGV 736_ SKPLP 741_ SVPPS 746_ IGKSN 751_ VDRRQ 756_ AEIGE 761_ GSVRR 766_ RIYDN 771_ PYFEP 776_ QYGFP 781_ PEEDE 786_ DEQGE 791_ SYTPR 796_ FSQHV 801_ SGNRA 806_ QKLLR 811_ PNSLR 816_ LASDS 821_ DAESD 826_ SRASS 831_ PNSTV 836_ SNTST 841_ EGFGG 846_ IMSFA 851_ SSLYR 856_ NHSTS 861_ FSLSN 866_ LTLPT 871_ KGARE 876_ KATPF 881_ PSLKV 886_ FGLNT 891_ LMEIV 896_ TEAGP 901_ GSGEG 906_ NRRAL 911_ VDQKS 916_ SVIKH 921_ SPTVK 926_ REPPS 931_ PQGRS 936_ SNSSE 941_ NQQFL 946_ KEVVH 951_ SVLDG 956_ QGVGW 961_ LNMKK 966_ VRRLL 971_ ESEQL 976_ RVFVL 981_ SKLNR 986_ MVQSE 991_ DDARQ 996_ DIIPD 1001_ VEISR 1006_ KVYKG 1011_ MLDLL 1016_ KCTVL 1021_ SLEQS 1026_ YAHAG 1031_ LGGMA 1036_ SIFGL 1041_ LEIAQ 1046_ THYYS 1051_ KEPDK 1056_ RKRSP 1061_ TESVN 1066_ TPVGK 1071_ DPGLA 1076_ GRGDP 1081_ KAMAQ 1086_ LRVPQ 1091_ LGPRA 1096_ PSATG 1101_ KGPKE 1106_ LDTRS 1111_ LKEEN 1116_ FIASI 1121_ ELWNK 1126_ HQEVK 1131_ KQKAL 1136_ EKQRP 1141_ EVIKP 1146_ VFDLG 1151_ ETEEK 1156_ KSQIS 1161_ ADSGV 1166_ SLTSS 1171_ SQRTD 1176_ QDSVI 1181_ GVSPA 1186_ VMIRS 1191_ SSQDS 1196_ EVSTV 1201_ VSNSS 1206_ GETLG 1211_ ADSDL 1216_ SSNAG 1221_ DGPGG 1226_ EGSVH 1231_ LASSR 1236_ GTLSD 1241_ SEIET 1246_ NSATS 1251_ TIFGK 1256_ AHSLK 1261_ PSIKE 1266_ KLAGS 1271_ PIRTS 1276_ EDVSQ 1281_ RVYLY 1286_ EGLLG 1291_ RDKGS 1296_ MWDQL 1301_ EDAAM 1306_ ETFSI 1311_ SKERS 1316_ TLWDQ 1321_ MQFWE 1326_ DAFLD 1331_ AVMLE 1336_ REGMG 1341_ MDQGP 1346_ QEMID 1351_ RYLSL 1356_ GEHDR 1361_ KRLED 1366_ DEDRL 1371_ LATLL 1376_ HNLIS 1381_ YMLLM 1386_ KVNKN 1391_ DIRKK 1396_ VRRLM 1401_ GKSHI 1406_ GLVYS 1411_ QQINE 1416_ VLDQL 1421_ ANLNG 1426_ RDLSI 1431_ WSSGS 1436_ RHMKK 1441_ QTFVV 1446_ HAGTD 1451_ TNGDI 1456_ FFMEV 1461_ CDDCV 1466_ VLRSN 1471_ IGTVY 1476_ ERWWY 1481_ EKLIN 1486_ MTYCP 1491_ KTKVL 1496_ CLWRR 1501_ NGSET 1506_ QLNKF 1511_ YTKKC 1516_ RELYY 1521_ CVKDS 1526_ MERAA 1531_ ARQQS 1536_ IKPGP 1541_ ELGGE 1546_ FPVQD 1551_ LKTGE 1556_ GGLLQ 1561_ VTLEG 1566_ INLKF 1571_ MHNQV 1576_ FIELN 1581_ HIKKC 1586_ NTVRG 1591_ VFVLE 1596_ EFVPE 1601_ IKEVV 1606_ SHKYK 1611_ TPMAH 1616_ EICYS 1621_ VLCLF 1626_ SYVAA 1631_ VHSSE 1636_ EDLRT 1641_PPRPV
1: Guanyl-nucleotide exchange factor that regulates small GTPases of the Rab family (PubMed:18559336, PubMed:20937701). Converts GDP-bound inactive form of RAB27A and RAB27B to the GTP-bound active forms (PubMed:18559336, PubMed:20937701). Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms, GTPases involved in synaptic vesicle exocytosis and vesicle secretion (By similarity). Plays a role in synaptic vesicle formation and in vesicle trafficking at the neuromuscular junction (By similarity). Involved in up-regulating a post-docking step of synaptic exocytosis in central synapses (By similarity). Probably by binding to the motor proteins KIF1B and KIF1A, mediates motor-dependent transport of GTP-RAB3A-positive vesicles to the presynaptic nerve terminals (By similarity). Plays a role in TNFA-mediated activation of the MAPK pathway, including ERK1/2 (PubMed:32761064). May link TNFRSF1A with MAP kinase activation (PubMed:9115275). May be involved in the regulation of TNFA-induced apoptosis (PubMed:11577081, PubMed:32761064)