Ankyrin repeat and SOCS box protein 11 (ASB-11)
1_MEDGP 6_ VFYGF 11_ KNIFI 16_ TMFAT 21_ FFFFK 26_ LLIKV 31_ FLALL 36_ THFYI 41_ VKGNR 46_ KEAAR 51_ IAEEI 56_ YGGIS 61_ DCWAD 66_ RSPLH 71_ EAAAQ 76_ GRLLA 81_ LKTLI 86_ AQGVN 91_ VNLVT 96_ INRVS 101_ SLHEA 106_ CLGGH 111_ VACAK 116_ ALLEN 121_ GAHVN 126_ GVTVH 131_ GATPL 136_ FNACC 141_ SGSAA 146_ CVNVL 151_ LEFGA 156_ KAQLE 161_ VHLAS 166_ PIHEA 171_ VKRGH 176_ RECME 181_ ILLAN 186_ NVNID 191_ HEVPQ 196_ LGTPL 201_ YVACT 206_ YQRVD 211_ CVKKL 216_ LELGA 221_ SVDHG 226_ QWLDT 231_ PLHAA 236_ ARQSN 241_ VEVIH 246_ LLTDY 251_ GANLK 256_ RRNAQ 261_ GKSAL 266_ DLAAP 271_ KSSVE 276_ QALLL 281_ REGPP 286_ ALSQL 291_ CRLCV 296_ RKCLG 301_ RACHQ 306_ AIHKL 311_ HLPEP 316_LERFL
1: Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as BIK, DIRAS2 and RPN1 (PubMed:24337577, PubMed:31387940, PubMed:38574733). The ECS(ASB11) complex acts as a regulator of the endoplasmic reticulum unfolded protein response by mediating ubiquitination and degradation of BIK (PubMed:31387940)