Suppressor of cytokine signaling 4 (SOCS-4) (Suppressor of cytokine signaling 7) (SOCS-7)
1_MAENN 6_ ENISK 11_ NVDVR 16_ PKTSR 21_ SRSAD 26_ RKDGY 31_ VWSGK 36_ KLSWS 41_ KKSES 46_ YSDAE 51_ TVNGI 56_ EKTEV 61_ SLRNQ 66_ ERKHS 71_ CSSIE 76_ LDLDH 81_ SCGHR 86_ FLGRS 91_ LKQKL 96_ QDAVG 101_ QCFPI 106_ KNCSS 111_ RHSSG 116_ LPSKR 121_ KIHIS 126_ ELMLD 131_ KCPFP 136_ PRSDL 141_ AFRWH 146_ FIKRH 151_ TAPIN 156_ SKSDE 161_ WVSTD 166_ LSQTE 171_ LRDGQ 176_ LKRRN 181_ MEENI 186_ NCFSH 191_ TNVQP 196_ CVITT 201_ DNALC 206_ REGPM 211_ TGSVM 216_ NLVSN 221_ NSIED 226_ SDMDS 231_ DDEIL 236_ TLCTS 241_ SRKRN 246_ KPKWD 251_ LDDEI 256_ LQLET 261_ PPKYH 266_ TQIDY 271_ VHCLV 276_ PDLLQ 281_ INNNP 286_ CYWGV 291_ MDKYA 296_ AEALL 301_ EGKPE 306_ GTFLL 311_ RDSAQ 316_ EDYLF 321_ SVSFR 326_ RYSRS 331_ LHARI 336_ EQWNH 341_ NFSFD 346_ AHDPC 351_ VFHSP 356_ DITGL 361_ LEHYK 366_ DPSAC 371_ MFFEP 376_ LLSTP 381_ LIRTF 386_ PFSLQ 391_ HICRT 396_ VICNC 401_ TTYDG 406_ IDALP 411_ IPSSM 416_ KLYLK 421_ EYHYK 426_ SKVRV 431_LRIDA
1: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR