Progesterone-induced-blocking factor 1 (PIBF) (Centrosomal protein of 90 kDa) (CEP90)
1_MSRKI 6_ SKESK 11_ KVNIS 16_ SSLES 21_ EDISL 26_ ETTVP 31_ TDDIS 36_ SSEER 41_ EGKVR 46_ ITRQL 51_ IERKE 56_ LLHNI 61_ QLLKI 66_ ELSQK 71_ TMMID 76_ NLKVD 81_ YLTKI 86_ EELEE 91_ KLNDA 96_ LHQKQ 101_ LLTLR 106_ LDNQL 111_ AFQQK 116_ DASKY 121_ QELMK 126_ QEMET 131_ ILLRQ 136_ KQLEE 141_ TNLQL 146_ REKAG 151_ DVRRN 156_ LRDFE 161_ LTEEQ 166_ YIKLK 171_ AFPED 176_ QLSIP 181_ EYVSV 186_ RFYEL 191_ VNPLR 196_ KEICE 201_ LQVKK 206_ NILAE 211_ ELSTN 216_ KNQLK 221_ QLTET 226_ YEEDR 231_ KNYSE 236_ VQIRC 241_ QRLAL 246_ ELADT 251_ KQLIQ 256_ QGDYR 261_ QENYD 266_ KVKSE 271_ RDALE 276_ QEVIE 281_ LRRKH 286_ EILEA 291_ SHMIQ 296_ TKERS 301_ ELSKE 306_ VVTLE 311_ QTVTL 316_ LQKDK 321_ EYLNR 326_ QNMEL 331_ SVRCA 336_ HEEDR 341_ LERLQ 346_ AQLEE 351_ SKKAR 356_ EEMYE 361_ KYVAS 366_ RDHYK 371_ TEYEN 376_ KLHDE 381_ LEQIR 386_ LKTNQ 391_ EIDQL 396_ RNASR 401_ EMYER 406_ ENRNL 411_ REARD 416_ NAVAE 421_ KERAV 426_ MAEKD 431_ ALEKH 436_ DQLLD 441_ RYREL 446_ QLSTE 451_ SKVTE 456_ FLHQS 461_ KLKSF 466_ ESERV 471_ QLLQE 476_ ETARN 481_ LTQCQ 486_ LECEK 491_ YQKKL 496_ EVLTK 501_ EFYSL 506_ QASSE 511_ KRITE 516_ LQAQN 521_ SEHQA 526_ RLDIY 531_ EKLEK 536_ ELDEI 541_ IMQTA 546_ EIENE 551_ DEAER 556_ VLFSY 561_ GYGAN 566_ VPTTA 571_ KRRLK 576_ QSVHL 581_ ARRVL 586_ QLEKQ 591_ NSLIL 596_ KDLEH 601_ RKDQV 606_ TQLSQ 611_ ELDRA 616_ NSLLN 621_ QTQQP 626_ YRYLI 631_ ESVRQ 636_ RDSKI 641_ DSLTE 646_ SIAQL 651_ EKDVS 656_ NLNKE 661_ KSALL 666_ QTKNQ 671_ MALDL 676_ EQLLN 681_ HREEL 686_ AAMKQ 691_ ILVKM 696_ HSKHS 701_ ENSLL 706_ LTKTE 711_ PKHVT 716_ ENQKS 721_ KTLNV 726_ PKEHE 731_ DNIFT 736_ PKPTL 741_ FTKKE 746_ APEWS 751_KKQKM
1: Plays a role in ciliogenesis
2: Pericentriolar protein required to maintain mitotic spindle pole integrity (PubMed:21224392). Required for the centrosomal accumulation of PCM1 and the recruitment of centriolar satellite proteins such as BBS4. Via association with PCM1 may be involved in primary cilia formation (PubMed:23110211). Required for CEP63 centrosomal localization and its interaction with WDR62. Together with CEP63 promotes centriole duplication. Promotes the centrosomal localization of CDK2 (PubMed:26297806)
3: The secreted form is a mediator of progesterone that by acting on the phospholipase A2 enzyme interferes with arachidonic acid metabolism, induces a Th2 biased immune response, and by controlling decidual natural killer cells (NK) activity exerts an anti-abortive effect (PubMed:12516630, PubMed:14634107, PubMed:3863495). Increases the production of Th2-type cytokines by signaling via the JAK/STAT pathway. Activates STAT6 and inhibits STAT4 phosphorylation. Signaling via a not identified receptor seems to implicate IL4R and a GPI-anchored protein (PubMed:16393965, PubMed:25218441)