Autism susceptibility gene 2 protein
1_MDGPT 6_ RGHGL 11_ RKKRR 16_ SRSQR 21_ DRERR 26_ SRGGL 31_ GAGAA 36_ GGGGA 41_ GRTRA 46_ LSLAS 51_ SSGSD 56_ KEDNG 61_ KPPSS 66_ APSRP 71_ RPPRR 76_ KRRES 81_ TSAEE 86_ DIIDG 91_ FAMTS 96_ FVTFE 101_ ALEKD 106_ VALKP 111_ QERVE 116_ KRQTP 121_ LTKKK 126_ REALT 131_ NGLSF 136_ HSKKS 141_ RLSHP 146_ HHYSS 151_ DREND 156_ RNLCQ 161_ HLGKR 166_ KKMPK 171_ ALRQL 176_ KPGQN 181_ SCRDS 186_ DSESA 191_ SGESK 196_ GFHRS 201_ SSRER 206_ LSDSS 211_ APSSL 216_ GTGYF 221_ CDSDS 226_ DQEEK 231_ ASDAS 236_ SEKLF 241_ NTVIV 246_ NKDPE 251_ LGVGT 256_ LPEHD 261_ SQDAG 266_ PIVPK 271_ ISGLE 276_ RSQEK 281_ SQDCC 286_ KEPIF 291_ EPVVL 296_ KDPCP 301_ QVAQP 306_ IPQPQ 311_ TEPQL 316_ RAPSP 321_ DPDLV 326_ QRTEA 331_ PPQPP 336_ PLSTQ 341_ PPQGP 346_ PEAQL 351_ QPAPQ 356_ PQVQR 361_ PPRPQ 366_ SPTQL 371_ LHQNL 376_ PPVQA 381_ HPSAQ 386_ SLSQP 391_ LSAYN 396_ SSSLS 401_ LNSLS 406_ SSRSS 411_ TPAKT 416_ QPAPP 421_ HISHH 426_ PSASP 431_ FPLSL 436_ PNHSP 441_ LHSFT 446_ PTLQP 451_ PAHSH 456_ HPNMF 461_ APPTA 466_ LPPPP 471_ PLTSG 476_ SLQVA 481_ GHPAG 486_ STYSE 491_ QDILR 496_ QELNT 501_ RFLAS 506_ QSADR 511_ GASLG 516_ PPPYL 521_ RTEFH 526_ QHQHQ 531_ HQHTH 536_ QHTHQ 541_ HTFTP 546_ FPHAI 551_ PPTAI 556_ MPTPA 561_ PPMFD 566_ KYPTK 571_ VDPFY 576_ RHSLF 581_ HSYPP 586_ AVSGI 591_ PPMIP 596_ PTGPF 601_ GSLQG 606_ AFQPK 611_ TSNPI 616_ DVAAR 621_ PGTVP 626_ HTLLQ 631_ KDPRL 636_ TDPFR 641_ PMLRK 646_ PGKWC 651_ AMHVH 656_ IAWQI 661_ YHHQQ 666_ KVKKQ 671_ MQSDP 676_ HKLDF 681_ GLKPE 686_ FLSRP 691_ PGPSL 696_ FGAIH 701_ HPHDL 706_ ARPST 711_ LFSAA 716_ GAAHP 721_ TGTPF 726_ GPPPH 731_ HSNFL 736_ NPAAH 741_ LEPFN 746_ RPSTF 751_ TGLAA 756_ VGGNA 761_ FGGLG 766_ NPSVT 771_ PNSMF 776_ GHKDG 781_ PSVQN 786_ FSNPH 791_ EPWNR 796_ LHRTP 801_ PSFPT 806_ PPPWL 811_ KPGEL 816_ ERSAS 821_ AAAHD 826_ RDRDV 831_ DKRDS 836_ SVSKD 841_ DKERE 846_ SVEKR 851_ HSSHP 856_ SPAPV 861_ LPVNA 866_ LGHTR 871_ SSTEQ 876_ IRAHL 881_ NTEAR 886_ EKDKP 891_ KERER 896_ DHSES 901_ RKDLA 906_ ADEHK 911_ AKEGH 916_ LPEKD 921_ GHGHE 926_ GRAAG 931_ EEAKQ 936_ LARVP 941_ SPYVR 946_ TPVVE 951_ SARPN 956_ STSSR 961_ EAEPR 966_ KGEPA 971_ YENPK 976_ KSSEV 981_ KVKEE 986_ RKEDH 991_ DLPPE 996_ APQTH 1001_ RASEP 1006_ PPPNS 1011_ SSSVH 1016_ PGPLA 1021_ SMPMT 1026_ VGVTG 1031_ IHPMN 1036_ SISSL 1041_ DRTRM 1046_ MTPFM 1051_ GISPL 1056_ PGGER 1061_ FPYPS 1066_ FHWDP 1071_ IRDPL 1076_ RDPYR 1081_ ELDIH 1086_ RRDPL 1091_ GRDFL 1096_ LRNDP 1101_ LHRLS 1106_ TPRLY 1111_ EADRS 1116_ FRDRE 1121_ PHDYS 1126_ HHHHH 1131_ HHHPL 1136_ SVDPR 1141_ REHER 1146_ GGHLD 1151_ ERERL 1156_ HMLRE 1161_ DYEHT 1166_ RLHSV 1171_ HPASL 1176_ DGHLP 1181_ HPSLI 1186_ TPGLP 1191_ SMHYP 1196_ RISPT 1201_ AGNQN 1206_ GLLNK 1211_ TPPTA 1216_ ALSAP 1221_ PPLIS 1226_ TLGGR 1231_ PVSPR 1236_ RTTPL 1241_ SAEIR 1246_ ERPPS 1251_HTLKD
1: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:25519132). The PRC1-like complex that contains PCGF5, RNF2, CSNK2B, RYBP and AUTS2 has decreased histone H2A ubiquitination activity, due to the phosphorylation of RNF2 by CSNK2B (PubMed:25519132). As a consequence, the complex mediates transcriptional activation (PubMed:25519132). In the cytoplasm, plays a role in axon and dendrite elongation and in neuronal migration during embryonic brain development. Promotes reorganization of the actin cytoskeleton, lamellipodia formation and neurite elongation via its interaction with RAC guanine nucleotide exchange factors, which then leads to the activation of RAC1 (By similarity)