E3 ubiquitin-protein ligase MYLIP (EC 2.3.2.27) (Inducible degrader of the LDL-receptor) (Idol) (Myosin regulatory light chain interacting protein) (MIR) (RING-type E3 ubiquitin transferase MYLIP)
1_MLCYV 6_ TRPDA 11_ VLMEV 16_ EVEAK 21_ ANGED 26_ CLNQV 31_ CRRLG 36_ IIEVD 41_ YFGLQ 46_ FTGSK 51_ GESLW 56_ LNLRN 61_ RISQQ 66_ MDGLA 71_ PYRLK 76_ LRVKF 81_ FVEPH 86_ LILQE 91_ QTRHI 96_ FFLHI 101_ KEALL 106_ AGHLL 111_ CSPEQ 116_ AVELS 121_ ALLAQ 126_ TKFGD 131_ YNQNT 136_ AKYNY 141_ EELCA 146_ KELSS 151_ ATLNS 156_ IVAKH 161_ KELEG 166_ TSQAS 171_ AEYQV 176_ LQIVS 181_ AMENY 186_ GIEWH 191_ SVRDS 196_ EGQKL 201_ LIGVG 206_ PEGIS 211_ ICKDD 216_ FSPIN 221_ RIAYP 226_ VVQMA 231_ TQSGK 236_ NVYLT 241_ VTKES 246_ GNSIV 251_ LLFKM 256_ ISTRA 261_ ASGLY 266_ RAITE 271_ THAFY 276_ RCDTV 281_ TSAVM 286_ MQYSR 291_ DLKGH 296_ LASLF 301_ LNENI 306_ NLGKK 311_ YVFDI 316_ KRTSK 321_ EVYDH 326_ ARRAL 331_ YNAGV 336_ VDLVS 341_ RNNQS 346_ PSHSP 351_ LKSSE 356_ SSMNC 361_ SSCEG 366_ LSCQQ 371_ TRVLQ 376_ EKLRK 381_ LKEAM 386_ LCMVC 391_ CEEEI 396_ NSTFC 401_ PCGHT 406_ VCCES 411_ CAAQL 416_ QSCPV 421_ CRSRV 426_ EHVQH 431_ VYLPT 436_HTSLL
1: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR