Peroxynitrite isomerase THAP4 (EC 5.99.-.-) (Ferric Homo sapiens nitrobindin) (Hs-Nb(III)) (THAP domain-containing protein 4)
1_MVICC 6_ AAVNC 11_ SNRQG 16_ KGEKR 21_ AVSFH 26_ RFPLK 31_ DSKRL 36_ IQWLK 41_ AVQRD 46_ NWTPT 51_ KYSFL 56_ CSEHF 61_ TKDSF 66_ SKRLE 71_ DQHRL 76_ LKPTA 81_ VPSIF 86_ HLTEK 91_ KRGAG 96_ GHGRT 101_ RRKDA 106_ SKATG 111_ GVRGH 116_ SSAAT 121_ SRGAA 126_ GWSPS 131_ SSGNP 136_ MAKPE 141_ SRRLK 146_ QAALQ 151_ GEATP 156_ RAAQE 161_ AASQE 166_ QAQQA 171_ LERTP 176_ GDGLA 181_ TMVAG 186_ SQGKA 191_ EASAT 196_ DAGDE 201_ SATSS 206_ IEGGV 211_ TDKSG 216_ ISMDD 221_ FTPPG 226_ SGACK 231_ FIGSL 236_ HSYSF 241_ SSKHT 246_ RERPS 251_ VPREP 256_ IDRKR 261_ LKKDV 266_ EPSCS 271_ GSSLG 276_ PDKGL 281_ AQSPP 286_ SSSLT 291_ ATPQK 296_ PSQSP 301_ SAPPA 306_ DVTPK 311_ PATEA 316_ VQSEH 321_ SDASP 326_ MSINE 331_ VILSA 336_ SGACK 341_ LIDSL 346_ HSYCF 351_ SSRQN 356_ KSQVC 361_ CLREQ 366_ VEKKN 371_ GELKS 376_ LRQRV 381_ SRSDS 386_ QVRKL 391_ QEKLD 396_ ELRRV 401_ SVPYP 406_ SSLLS 411_ PSREP 416_ PKMNP 421_ VVEPL 426_ SWMLG 431_ TWLSD 436_ PPGAG 441_ TYPTL 446_ QPFQY 451_ LEEVH 456_ ISHVG 461_ QPMLN 466_ FSFNS 471_ FHPDT 476_ RKPMH 481_ RECGF 486_ IRLKP 491_ DTNKV 496_ AFVSA 501_ QNTGV 506_ VEVEE 511_ GEVNG 516_ QELCI 521_ ASHSI 526_ ARISF 531_ AKEPH 536_ VEQIT 541_ RKFRL 546_ NSEGK 551_ LEQTV 556_ SMATT 561_ TQPMT 566_ QHLHV 571_TYKKV
1: Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate. Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively). Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo, possibly modulating the transcriptional activity residing in the N-terminal region