Inhibitor of growth protein 5 (p28ING5)
1_MATAM 6_ YLEHY 11_ LDSIE 16_ NLPCE 21_ LQRNF 26_ QLMRE 31_ LDQRT 36_ EDKKA 41_ EIDIL 46_ AAEYI 51_ STVKT 56_ LSPDQ 61_ RVERL 66_ QKIQN 71_ AYSKC 76_ KEYSD 81_ DKVQL 86_ AMQTY 91_ EMVDK 96_ HIRRL 101_ DADLA 106_ RFEAD 111_ LKDKM 116_ EGSDF 121_ ESSGG 126_ RGLKK 131_ GRGQK 136_ EKRGS 141_ RGRGR 146_ RTSEE 151_ DTPKK 156_ KKHKG 161_ GSEFT 166_ DTILS 171_ VHPSD 176_ VLDMP 181_ VDPNE 186_ PTYCL 191_ CHQVS 196_ YGEMI 201_ GCDNP 206_ DCPIE 211_ WFHFA 216_ CVDLT 221_ TKPKG 226_ KWFCP 231_RCVQE
1: Component of the HBO1 complex, which specifically mediates acetylation of histone H3 at 'Lys-14' (H3K14ac) and, to a lower extent, acetylation of histone H4 (PubMed:24065767). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (PubMed:16387653). Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator (PubMed:12750254, PubMed:16387653). Inhibits cell growth, induces a delay in S-phase progression and enhances Fas-induced apoptosis in an INCA1-dependent manner (PubMed:21750715)