Jun dimerization protein 2
1_MMPGQ 6_ IPDPS 11_ VTTGS 16_ LPGLG 21_ PLTGL 26_ PSSAL 31_ TVEEL 36_ KYADI 41_ RNLGA 46_ MIAPL 51_ HFLEV 56_ KLGKR 61_ PQPVK 66_ SELDE 71_ EEERR 76_ KRRRE 81_ KNKVA 86_ AARCR 91_ NKKKE 96_ RTEFL 101_ QRESE 106_ RLELM 111_ NAELK 116_ TQIEE 121_ LKQER 126_ QQLIL 131_ MLNRH 136_ RPTCI 141_ VRTDS 146_ VKTPE 151_ SEGNP 156_LLEQL
1: Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1 such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin