Transmembrane O-methyltransferase (EC 2.1.1.6) (Catechol O-methyltransferase 2) (Protein LRTOMT2)
1_MGTPW 6_ RKRKG 11_ IAGPG 16_ LPDLS 21_ CALVL 26_ QPRAQ 31_ VGTMS 36_ PAIAL 41_ AFLPL 46_ VVTLL 51_ VRYRH 56_ YFRLL 61_ VRTVL 66_ LRSLR 71_ DCLSG 76_ LRIEE 81_ RAFSY 86_ VLTHA 91_ LPGDP 96_ GHILT 101_ TLDHW 106_ SSRCE 111_ YLSHM 116_ GPVKG 121_ QILMR 126_ LVEEK 131_ APACV 136_ LELGT 141_ YCGYS 146_ TLLIA 151_ RALPP 156_ GGRLL 161_ TVERD 166_ PRTAA 171_ VAEKL 176_ IRLAG 181_ FDEHM 186_ VELIV 191_ GSSED 196_ VIPCL 201_ RTQYQ 206_ LSRAD 211_ LVLLA 216_ HRPRC 221_ YLRDL 226_ QLLEA 231_ HALLP 236_ AGATV 241_ LADHV 246_ LFPGA 251_ PRFLQ 256_ YAKSC 261_ GRYRC 266_ RLHHT 271_ GLPDF 276_ PAIKD 281_ GIAQL 286_TYAGP
1: Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones (By similarity). Required for auditory function (PubMed:18794526). Component of the cochlear hair cell's mechanotransduction (MET) machinery. Involved in the assembly of the asymmetric tip-link MET complex. Required for transportation of TMC1 and TMC2 proteins into the mechanically sensitive stereocilia of the hair cells. The function in MET is independent of the enzymatic activity (By similarity)