BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 (hBACURD1) (BTB/POZ domain-containing protein KCTD13) (Polymerase delta-interacting protein 1) (TNFAIP1-like protein)
1_MSAEA 6_ SGPAA 11_ AAAPS 16_ LEAPK 21_ PSGLE 26_ PGPAA 31_ YGLKP 36_ LTPNS 41_ KYVKL 46_ NVGGS 51_ LHYTT 56_ LRTLT 61_ GQDTM 66_ LKAMF 71_ SGRVE 76_ VLTDA 81_ GGWVL 86_ IDRSG 91_ RHFGT 96_ ILNYL 101_ RDGSV 106_ PLPES 111_ TRELG 116_ ELLGE 121_ ARYYL 126_ VQGLI 131_ EDCQL 136_ ALQQK 141_ RETLS 146_ PLCLI 151_ PMVTS 156_ PREEQ 161_ QLLAS 166_ TSKPV 171_ VKLLH 176_ NRSNN 181_ KYSYT 186_ STSDD 191_ NLLKN 196_ IELFD 201_ KLALR 206_ FHGRL 211_ LFLKD 216_ VLGDE 221_ ICCWS 226_ FYGQG 231_ RKIAE 236_ VCCTS 241_ IVYAT 246_ EKKQT 251_ KVEFP 256_ EARIF 261_ EETLN 266_ ILIYE 271_ TPRGP 276_ DPALL 281_ EATGG 286_ AAGAG 291_ GAGRG 296_ EDEEN 301_ REHRV 306_ RRIHV 311_ RRHIT 316_ HDERP 321_HGQQI
1: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for synaptic transmission (PubMed:19782033). The BCR(KCTD13) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome (PubMed:19782033) Degradation of RHOA regulates the actin cytoskeleton and promotes synaptic transmission (By similarity)