Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14)
1_!!! T 6_ O LON 11_ G IT 16_ DOES 21_ NOT F 26_ IT IN 31_ EXCE 36_ LL, N 41_ OT RE 46_ PRESE 51_ NTABL 56_ E IN 61_EXCEL
1: Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase