Barttin
1_MADEK 6_ TFRIG 11_ FIVLG 16_ LFLLA 21_ LGTFL 26_ MSHDR 31_ PQVYG 36_ TFYAM 41_ GSVMV 46_ IGGII 51_ WSMCQ 56_ CYPKI 61_ TFVPA 66_ DSDFQ 71_ GILSP 76_ KAMGL 81_ LENGL 86_ AAEMK 91_ SPSPQ 96_ PPYVR 101_ LWEEA 106_ AYDQS 111_ LPDFS 116_ HIQMK 121_ VMSYS 126_ EDHRS 131_ LLAPE 136_ MGQPK 141_ LGTSD 146_ GGEGG 151_ PGDVQ 156_ AWMEA 161_ AVVIH 166_ KGSDE 171_ SEGER 176_ RLTQS 181_ WPGPL 186_ ACPQG 191_ PAPLA 196_ SFQDD 201_ LDMDS 206_ SEGSS 211_ PNASP 216_ HDREE 221_ ACSPQ 226_ QEPQG 231_ CRCPL 236_ DRFQD 241_ FALID 246_ APTLE 251_ DEPQE 256_ GQQWE 261_ IALPN 266_ NWQRY 271_ PRTKV 276_ EEKEA 281_ SDTGG 286_ EEPEK 291_ EEEDL 296_ YYGLP 301_ DGAGD 306_ LLPDK 311_ELGFE
1: Regulatory subunit of anion-selective CLCNKA:BSND and CLCNKB:BSND heteromeric channels involved in basolateral chloride conductance along the nephron to achieve urine concentration and maintain systemic acid-base homeostasis, and in the stria vascularis of the inner ear to establish the endocochlear potential necessary for normal hearing (PubMed:11734858, PubMed:12111250, PubMed:12574213, PubMed:16849430, PubMed:18776122, PubMed:19646679, PubMed:20538786, PubMed:26013830). Most likely acts as a chaperone that allosterically regulates proper sorting of CLCNKA:BSND and CLCNKB:BSND channels at the basolateral plasma membrane domain and functional switch to ion conducting state. Mediates constitutive opening of channel common gates (PubMed:11734858, PubMed:12111250, PubMed:12574213, PubMed:16849430, PubMed:18776122, PubMed:19646679, PubMed:20538786, PubMed:26013830)