Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 (Centaurin-delta-1) (Cnt-d1) (Protein PARX)
1_MSSVS 6_ EVNVD 11_ IKDFL 16_ MSINL 21_ EQYLL 26_ HFHES 31_ GFTTV 36_ KDCAA 41_ INDSL 46_ LQKIG 51_ ISPTG 56_ HRRRI 61_ LKQLQ 66_ IILSK 71_ MQDIP 76_ IYANV 81_ HKTKK 86_ NDDPS 91_ KDYHV 96_ PSSDQ 101_ NICIE 106_ LSNSG 111_ SVQTS 116_ SPPQL 121_ ETVRK 126_ NLEDS 131_ DASVE 136_ RSQYP 141_ QSDDK 146_ LSPPK 151_ RDFPT 156_ AEEPH 161_ LNLGS 166_ LNDSL 171_ FGSDN 176_ IKIES 181_ LITKK 186_ TVDHT 191_ VEEQQ 196_ TEKVK 201_ LITEN 206_ LSKLP 211_ NADSE 216_ CLSFV 221_ GCSTS 226_ GTNSG 231_ NGTNG 236_ LLEGS 241_ PPSPF 246_ FKFQG 251_ EMIVN 256_ DLYVP 261_ SSPIL 266_ APVRS 271_ RSKLV 276_ SRPSR 281_ SFLLR 286_ HRPVP 291_ EIPGS 296_ TKGVS 301_ GSYFR 306_ ERRNV 311_ ATSTE 316_ KSVAW 321_ QNSNE 326_ ENSSS 331_ IFPYG 336_ ETFLF 341_ QRLEN 346_ SKKRS 351_ IKNEF 356_ LTQGE 361_ ALKGE 366_ AATAT 371_ NSFII 376_ KSSIY 381_ DNRKE 386_ KISED 391_ KVEDI 396_ WIPRE 401_ DKNNF 406_ LIDTA 411_ SESEY 416_ STVEE 421_ CFQSL 426_ RRKNS 431_ KASKS 436_ RTQKA 441_ LILDS 446_ VNRHS 451_ YPLSS 456_ TSGNA 461_ DSSAV 466_ SSQAI 471_ SPYAC 476_ FYGAS 481_ AKKVK 486_ SGWLD 491_ KLSPQ 496_ GKRMF 501_ QKRWV 506_ KFDGL 511_ SISYY 516_ NNEKE 521_ MYSKG 526_ IIPLS 531_ AISTV 536_ RVQGD 541_ NKFEV 546_ VTTQR 551_ TFVFR 556_ VEKEE 561_ ERNDW 566_ ISILL 571_ NALKS 576_ QSLTS 581_ QSQAV 586_ VTPEK 591_ CGYLE 596_ LRGYK 601_ AKIFT 606_ VLSGN 611_ SVWLC 616_ KNEQD 621_ FKSGL 626_ GITII 631_ PMNVA 636_ NVKQV 641_ DRTVK 646_ QSFEI 651_ ITPYR 656_ SFSFT 661_ AETEK 666_ EKQDW 671_ IEAVQ 676_ QSIAE 681_ TLSDY 686_ EVAEK 691_ IWFNE 696_ SNRSC 701_ ADCKA 706_ PDPDW 711_ ASINL 716_ CVVIC 721_ KKCAG 726_ QHRSL 731_ GPKDS 736_ KVRSL 741_ KMDAS 746_ IWSNE 751_ LIELF 756_ IVIGN 761_ KRAND 766_ FWAGN 771_ LQKDE 776_ ELHMD 781_ SPVEK 786_ RKNFI 791_ TQKYK 796_ EGKFR 801_ KTLLA 806_ SLTKE 811_ ELNKA 816_ LCAAV 821_ VKPDV 826_ LETMA 831_ LLFSG 836_ ADVMC 841_ ATGDP 846_ VHSTP 851_ YLLAK 856_ KAGQS 861_ LQMEF 866_ LYHNK 871_ FSDFP 876_ QHDIH 881_ SEGVL 886_ SQESS 891_ QSTFL 896_ CDFLY 901_ QAPSA 906_ ASKLS 911_ SEKKL 916_ LEETN 921_ KKWCV 926_ LEGGF 931_ LSYYE 936_ NDKST 941_ TPNGT 946_ ININE 951_ VICLA 956_ IHKED 961_ FYLNT 966_ GPIFI 971_ FEIYL 976_ PSERV 981_ FLFGA 986_ ETSQA 991_ QRKWT 996_ EAIAK 1001_ HFVPL 1006_ FAENL 1011_ TEADY 1016_ DLIGQ 1021_ LFYKD 1026_ CHALD 1031_ QWRKG 1036_ WFAMD 1041_ KSSLH 1046_ FCLQM 1051_ QEVQG 1056_ DRMHL 1061_ RRLQE 1066_ LTIST 1071_ MVQNG 1076_ EKLDV 1081_ LLLVE 1086_ KGRTL 1091_ YIHGH 1096_ TKLDF 1101_ TVWHT 1106_ AIEKA 1111_ AGTDG 1116_ NALQD 1121_ QQLSK 1126_ NDVPI 1131_ IVNSC 1136_ IAFVT 1141_ QYGLG 1146_ CKYIY 1151_ QKNGD 1156_ PLHIS 1161_ ELLES 1166_ FKKDA 1171_ RSFKL 1176_ RAGKH 1181_ QLEDV 1186_ TAVLK 1191_ SFLSD 1196_ IDDAL 1201_ LTKEL 1206_ YPYWI 1211_ SALDT 1216_ QDDKE 1221_ RIKKY 1226_ GAFIR 1231_ SLPGV 1236_ NRATL 1241_ AAIIE 1246_ HLYRV 1251_ QKCSE 1256_ INHMN 1261_ AHNLA 1266_ LVFSS 1271_ CLFQT 1276_ KGQTS 1281_ EEVNV 1286_ IEDLI 1291_ NNYVE 1296_ IFEVK 1301_ EDQVK 1306_ QMDIE 1311_ NSFIT 1316_ KWKDT 1321_ QVSQA 1326_ GDLLI 1331_ EVYVE 1336_ RKEPD 1341_ CSIII 1346_ RISPV 1351_ MEAEE 1356_ LTNDI 1361_ LAIKN 1366_ IIPTK 1371_ GDIWA 1376_ TFEVI 1381_ ENEEL 1386_ ERPLH 1391_ YKENV 1396_ LEQVL 1401_ RWSSL 1406_ AEPGS 1411_ AYLVV 1416_ KRFLT 1421_ ADTIK 1426_ HCSDR 1431_ STLGS 1436_ IKEGI 1441_ LKIKE 1446_ EPSKI 1451_ LSGNK 1456_ FQDRY 1461_ FVLRD 1466_ GFLFL 1471_ YKDVK 1476_ SSKHD 1481_ KMFSL 1486_ SSMKF 1491_ YRGVK 1496_ KKMKP 1501_ PTSWG 1506_ LTAYS 1511_ EKHHW 1516_ HLCCD 1521_ SSRTQ 1526_ TEWMT 1531_ SIFIA 1536_ QHEYD 1541_ IWPPA 1546_ GKERK 1551_ RSITK 1556_ NPKIG 1561_ GLPLI 1566_ PIQHE 1571_ GNATL 1576_ ARKNI 1581_ ESARA 1586_ ELERL 1591_ RLSEK 1596_ CDKES 1601_ VDSSL 1606_ KERAS 1611_ MVAHC 1616_ LEHKD 1621_ DKLRN 1626_ RPRKH 1631_ RSFNC 1636_ LEDTE 1641_ PEAPL 1646_ GQPKG 1651_ HKGLK 1656_ TLRKT 1661_ EDRNS 1666_ KATLD 1671_ SDHKL 1676_ PSRVI 1681_ EELNV 1686_ VLQRS 1691_ RTLPK 1696_ELQDE
1: Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency (By similarity)